Adult-Onset Still's Disease with Submassive Hepatic Necrosis

Akiyoshi TAKAMI; Shinji NAKAO; Hirotoshi MIYAMORI; Motoshi OOI; Toshihiko MACHI; Tatsuya CHUJO; Tetsuya NAKAZAWA; Yasuhito SAITO; Masahiro KANNO; Tamotsu MATSUDA; Shunsuke KITAGAWA

doi:10.2169/internalmedicine.34.89

Akiyoshi TAKAMI, Shinji NAKAO, Hirotoshi MIYAMORI, Motoshi OOI, Toshihiko MACHI, Tatsuya CHUJO, Tetsuya NAKAZAWA, Yasuhito SAITO, Masahiro KANNO, Tamotsu MATSUDA, Shunsuke KITAGAWA

Author information

Akiyoshi TAKAMI
the Departments of Medicine, Kenju General Hospital
the Third Department of Medicine, Kanazawa University School of Medicine
Shinji NAKAO
the Third Department of Medicine, Kanazawa University School of Medicine
Hirotoshi MIYAMORI
the Departments of Medicine, Kenju General Hospital
Motoshi OOI
the First Department of Pathology, Kanazawa University School of Medicine
Toshihiko MACHI
the Departments of Medicine, Kenju General Hospital
Tatsuya CHUJO
the Departments of Medicine, Kenju General Hospital
Tetsuya NAKAZAWA
the Departments of Medicine, Kenju General Hospital
Yasuhito SAITO
the Departments of Medicine, Kenju General Hospital
Masahiro KANNO
the Departments of Surgery, Keiju General Hospital
Tamotsu MATSUDA
the Third Department of Medicine, Kanazawa University School of Medicine
Shunsuke KITAGAWA
the Departments of Medicine, Kenju General Hospital

Keywords: fever of unknown origin, liver dysfunction, piecemeal necrosis, lymphadenopathy, corticosteroid therapy

JOURNAL FREE ACCESS

1995 Volume 34 Issue 2 Pages 89-91

DOI https://doi.org/10.2169/internalmedicine.34.89

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Abstract

We present a 74-year old woman who was hospitalized because of typical spiking fever, evanescent rash, polyarthralgia, lymphadenopathy, and marked elevation of serum transaminases and lactate dehydrogenase (LDH) due to adult-onset Still's disease (AOSD) with submassive hepatic necrosis. All of the symptoms and abnormal laboratory findings were dramatically improved after treatment with prednisolone. The clinical course of this patient indicates that AOSD with severe hepatic necrosis can successfully be treated with early administration of corticosteroid, although it remains unknown whether the disease can remain in remission with no or minimal treatment.
(Internal Medicine 34: 89-91, 1995)

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