Back to Journals » International Journal of Nephrology and Renovascular Disease » Volume 5
High burden and unmet patient needs in chronic kidney disease
Authors Braun, Sood V, Hogue S, Lieberman, Copley-Merriman
Received 5 September 2012
Accepted for publication 9 October 2012
Published 13 December 2012 Volume 2012:5 Pages 151—163
DOI https://doi.org/10.2147/IJNRD.S37766
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
LeeAnn Braun,1 Vipan Sood,2 Susan Hogue,1 Bonnie Lieberman,2 Catherine Copley-Merriman1
1RTI Health Solutions, Ann Arbor, MI, 2Mitsubishi Tanabe Pharma America, Inc, Warren, NJ, USA
Abstract: Chronic kidney disease (CKD) is a complex debilitating condition affecting more than 70 million people worldwide. With the increased prevalence in risk factors such as diabetes, hypertension, and cardiovascular disease in an aging population, CKD prevalence is also expected to increase. Increased awareness and understanding of the overall CKD burden by health care teams (patients, clinicians, and payers) is warranted so that overall care and treatment management may improve. This review of the burden of CKD summarizes available evidence of the clinical, humanistic, and economic burden of CKD and the current unmet need for new treatments and serves as a resource on the overall burden. Across countries, CKD prevalence varies considerably and is dependent upon patient characteristics. The prevalence of risk factors including diabetes, hypertension, cardiovascular disease, and congestive heart failure is noticeably higher in patients with lower estimated glomerular filtration rates (eGFRs) and results in highly complex CKD patient populations. As CKD severity worsens, there is a subsequent decline in patient health-related quality of life and an increased use of health care resources as well as burgeoning costs. With current treatment, nearly half of patients progress to unfavorable renal and cardiovascular outcomes. Although curative treatment that will arrest kidney deterioration is desired, innovative agents under investigation for CKD to slow kidney deterioration, such as atrasentan, bardoxolone methyl, and spherical carbon adsorbent, may offer patients healthier and more productive lives.
Keywords: quality of life, economics, disease classification, treatment, eGFR
© 2012 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.