The Journal of Toxicological Sciences
Online ISSN : 1880-3989
Print ISSN : 0388-1350
ISSN-L : 0388-1350
Toxicogenomics/proteomics Report
Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury
Gi-Wook Hwang, Jin-Yong Lee, Katsunori Ryoke, Fujio Matsuyama, Jong-Mu Kim, Tsutomu Takahashi, Akira Naganuma
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Keywords: Methylmercury, Gene expression, Mice, Cerebellum, Chemokines
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2011 Volume 36 Issue 3 Pages 389-391

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Abstract

To elucidate the molecular mechanism involved in methylmercury-induced cerebellar disorder, we performed DNA microarray analysis of the cerebellum of methylmercury-treated mice. The expression levels of 21 genes were elevated 2-fold or higher in response to methylmercury, including many genes encoding proteins involved in inflammatory reactions associated with chemokines. The expression levels of 11 genes were reduced by half or more in response to methylmercury.

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© 2011 The Japanese Society of Toxicology
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