Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
JCR Impact Factor (IF) – 2.1
5-Year Impact Factor – 2.2
Scopus CiteScore – 3.4 (CiteScore Tracker 3.7)
Index Copernicus  – 161.11; MNiSW – 70 pts

ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
Periodicity – monthly

Download original text (EN)

Advances in Clinical and Experimental Medicine

2018, vol. 27, nr 9, September, p. 1303–1307

doi: 10.17219/acem/69133

Publication type: review

Language: English

Download citation:

  • BIBTEX (JabRef, Mendeley)
  • RIS (Papers, Reference Manager, RefWorks, Zotero)

The role of ultrasonography in the diagnostic criteria for rheumatoid arthritis and monitoring its therapeutic efficacy

Sławomir Jeka1,A, Marta Dura2,3,A,B, Paweł Zuchowski4,A,D, Beata Zwierko2,B, Marzena Waszczak-Jeka5,B

1 Clinic of Rheumatology and Systemic Connective Tissue Disorders, Jan Biziel University Hospital No. 2, Ludwik Rydygier Collegium Medicum in Bydgoszcz, UMK in Toruń, Poland

2 Department of Radiology, Jan Biziel University Hospital No. 2, Bydgoszcz, Poland

3 Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland

4 Clinic of Rheumatology and Systemic Connective Tissue Disorders, Jan Biziel University Hospital No. 2, Bydgoszcz, Poland

5 Centre for Clinical Trials, Warszawa, Poland

Abstract

Rheumatoid arthritis (RA) is a chronic systemic disease of connective tissue. It is characterized by symmetrical multiple joint involvement and extra-articular symptoms. Modern RA treatment methods place a particular emphasis on the earliest possible diagnosis and initiation of appropriate treatment. Currently, ultrasonography (US) is the key imaging test performed in RA patients. However, despite the general acknowledgement of its role in the assessment of disease activity, US was not included in the applicable ACR/EULAR criteria. This is due to the lack of strictly defined criteria for US evaluation and the interpretation of test results. In addition, the absence of a correlation between the common DAS/DAS28 disease activity score and ultrasound assessment of joints makes developing new diagnostic criteria difficult. The objective of this article is to review recent scientific reports on the use of ultrasonography in the diagnosis and monitoring of RA and to indicate current problems associated with the interpretation of test results and the comparison with applicable scores of disease activity.

Key words

rheumatoid arthritis, ultrasonography, synovitis

References (24)

  1. Migliore A, Bizzi E, Petrella L, et al. The challenge of treating early-stage rheumatoid arthritis: The contribution of mixed treatment comparison to choosing appropriate biologic agents. BioDrugs. 2016; 30:105–115.
  2. van Nies JA, Tsonaka R, Gaujoux-Viala C, et al. Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: Does a window of opportunity exist? Results on the Leiden early arthritis clinic and ESPOIR cohorts. Ann Rheum Dis. 2015;74:806–812.
  3. Świerkot J, Batko B, ed. Reumatoidalne zapalenie stawów: praktycz-ne aspekty leczenia. 1st ed. Poznań, Poland: Termedia Wydawnictwa Medyczne; 2016.
  4. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315–324.
  5. Szkudlarek M, Terslev L, Wakefield RJ, et al. Summary findings of a systematic literature review of the ultrasound assessment of bone erosions in rheumatoid arthritis. J Rheumatol. 2016;43:12–21.
  6. Boutry N, Morel M, Flipo RM, et al. Early rheumatoid arthritis: A review of MRI and sonographic findings. Am J Roentgenol. 2007;189:1502–1509.
  7. Piotto DG, Correa MJ, Miotto e Silva VB, et al. Laser Doppler imaging for assessment of microcirculation in juvenile systemic sclerosis. Rheumatology (Oxford). 2014;53:72–75.
  8. Naredo E, Wakefield RJ, Iagnocco A, et al. The OMERACT ultrasound task force-status and perspectives. J Rheumatol. 2011;38:2063–2067.
  9. Naredo E, Iagnocco A. Why use ultrasound in rheumatology? Rheumatology (Oxford). 2012;51(Suppl 7):vii1.
  10. Fiocco U, Ferro F, Vezzù M, et al. Rheumatoid and psoriatic knee synovitis: Clinical, grey scale, and power Doppler ultrasound assessment of the response to etanercept. Ann Rheum Dis. 2005;64:899–905.
  11. Finzel S, Ohrndorf S, Englbrecht M, et al. A detailed comparative study of high-resolution ultrasound and micro-computed tomography for detection of arthritic bone erosions. Arthritis Rheum. 2011;63: 1231–1236.
  12. Brown AK, Quinn MA, Karim Z, et al. Presence of significant synovitis in rheumatoid arthritis patients with disease modifying antirheumatic drug-induced clinical remission: Evidence from an imaging study may explain structural progression. Arthritis Rheum. 2006;54:3761–3773.
  13. Brown AK, Conaghan PG, Karim Z, et al. An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis. Arthritis Rheum. 2008;58:2958–2967.
  14. Sreerangaiah D, Grayer M, Fisher BA, et al. Quantitative power Doppler ultrasound measures of peripheral joint synovitis in poor prognosis early rheumatoid arthritis predict radiographic progression. Rheumatology (Oxford). 2016;55:89−93.
  15. D’Agostino MA, Boers M, Wakefield RJ, et al. Exploring a new ultrasound score as a clinical predictive tool in patients with rheumatoid arthritis starting abatacept: Results from the APPRAISE study. RMD Open. 2016;5,2:e000237.
  16. Smolen JS, Aletaha D, Bijlsma JW, et al. Treating rheumatoid arthritis to target: Recommendations of an international task force. Ann Rheum Dis. 2010;69:631–637.
  17. Smolen JS, Breedveld FC, Burmester GR, et al. Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. Ann Rheum Dis. 2016;75:3–15.
  18. Barczyńska TA, Dura M, Blumfield E, et al. DAS28 score vs ultrasound examination for assessment of rheumatoid arthritis disease activity: Comparison and discussion of pros and cons. Reumatologia. 2015; 4:213–218.
  19. Dejaco C, Duftner C, Wipfler-Freissmuth E, et al. Ultrasound-defined remission and active disease in rheumatoid arthritis: Association with clinical and serologic parameters. Semin Arthritis Rheum. 2012;41:761–767.
  20. Saleem B, Brown AK, Keen H, et al. Should imaging be a component of rheumatoid arthritis remission criteria? A comparison between traditional and modified composite remission scores and imaging assessments. Ann Rheum Dis. 2011;70:792–798.
  21. Balsa A, de Miguel E, Castillo C, et al. Superiority of SDAI over DAS-28 in assessment of remission in rheumatoid arthritis patients using power Doppler ultrasonography as a gold standard. Rheumatology (Oxford). 2010;49:683–690.
  22. Gärtner M, Mandl P, Radner H, et al. Sonographic joint assessment in rheumatoid arthritis: Associations with clinical joint assessment during a state of remission. Arthritis Rheum. 2013;65:2005–2014.
  23. Grassi W, Gaywood I, Pande I, et al. From DAS 28 to SAS 1. Clin Exp Rheumatol. 2012;30:649–651.
  24. Yoshimi R, Ihata A, Kunishita Y, et al. A novel 8-joint ultrasound score is useful in daily practice for rheumatoid arthritis. Mod Rheumatol. 2015;25:379–385.