The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Case Report
Pulmonary Lymphangioleiomyomatosis: A Case Report with Immunohistochemical Details and DNA Analysis
Li-Hua Pan, Harumasa Ito, Akira Kurose, Kohei Yamauchi, Hiroshi Inoue, Takashi Sawai
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Keywords: pulmonary lymphangioleiomyomatosis, HMB45
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2003 Volume 199 Issue 2 Pages 119-126

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Abstract

A 47-year-old woman is presented with pulmonary lymphangioleiomyomatosis (PLAM) involving the bilateral lung and slight pulmonary function abnormality. Computed tomography scan showed bilateral microcyst formation in the lung. Histologically, proliferating spindle shaped cells with centrilobular emphysema were main findings. Immunohistochemically, these proliferating spindle shaped cells were positive for α-smooth muscle actin, desmin, vimentin, HMB45, estrogen receptor and progesterone receptor, but negative for S-100, cytokeratin. Single strand conformation polymorphism (SSCP) and DNA analysis for tuberous sclerosis 1 and 2 showed no significant abnormality.

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