Evaluation of Myocardial Involvement in Duchenne's Progressive Muscular Dystrophy with Thallium-201 Myocardial Perfusion Imaging

Naoki KAWAI; Iwao SOTOBATA; Mitsuhiro OKADA; Masatsugu IWASE; Shuhei YAMAMOTO; Hideo MATSUSHIMA; Hiroyuki MIYAKODA; Mitsuhiro YOKOTA; Kazunobu YAMAUCHI; Hiroshi HAYASHI

doi:10.1536/ihj.26.767

Naoki KAWAI, Iwao SOTOBATA, Mitsuhiro OKADA, Masatsugu IWASE, Shuhei YAMAMOTO, Hideo MATSUSHIMA, Hiroyuki MIYAKODA, Mitsuhiro YOKOTA, Kazunobu YAMAUCHI, Hiroshi HAYASHI

Author information

Naoki KAWAI
First Department of Internal Medicine, Nagoya University School of Medicine
Iwao SOTOBATA
First Department of Internal Medicine, Nagoya University School of Medicine
Mitsuhiro OKADA
First Department of Internal Medicine, Nagoya University School of Medicine
Masatsugu IWASE
First Department of Internal Medicine, Nagoya University School of Medicine
Shuhei YAMAMOTO
First Department of Internal Medicine, Nagoya University School of Medicine
Hideo MATSUSHIMA
First Department of Internal Medicine, Nagoya University School of Medicine
Hiroyuki MIYAKODA
First Department of Internal Medicine, Nagoya University School of Medicine
Mitsuhiro YOKOTA
First Department of Internal Medicine, Nagoya University School of Medicine
Kazunobu YAMAUCHI
First Department of Internal Medicine, Nagoya University School of Medicine
Hiroshi HAYASHI
First Department of Internal Medicine, Nagoya University School of Medicine

Keywords: Thallium-201 myocardial scintigraphy, Progressive muscular disease, Transmission computed tomography, Secondary myocardial disease, Thoracic deformities, Cardiomyopathy, Serial scintigraphic studies

JOURNAL FREE ACCESS

1985 Volume 26 Issue 5 Pages 767-775

DOI https://doi.org/10.1536/ihj.26.767

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Abstract

Myocardial involvement in progressive muscular dystrophy of the Duchenne type was evaluated in 19 patients using thallium-201 myocardial perfusion imaging. A qualitative analysis was performed from five projection images by three experienced physicians. Distinct perfusion defects were shown in 13 patients, especially in the LV posterolateral or posterior wall (11 patients). There was no significant relationship between the presence of perfusion defects and the skeletal muscle involvements or thoracic deformities assessed by transmission computed tomography. Extensive perfusion defects were shown in 2 patients who died of congestive heart failure 1 to 2 years after the scintigraphic study.Progression of the myocardial scintigraphic abnormalities were considered to be minimal in 7 of 9 patients who underwent two serial scintigraphic studies over 2 to 3 years. It was concluded that thallium myocardial perfusion imaging is a useful clinical technique to assess myocardial involvement in Duchenne's progressive muscular dystrophy.

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