Surgical management of primary thyroid carcinoma arising in thyroglossal duct cyst: An experience of a single institution in Serbia

Radan Dzodic; Ivan Markovic; Boban Stanojevic; Vladimir Saenko; Marko Buta; Igor Djurisic; Merima Oruci; Gordana Pupic; Zorka Milovanovic; Shunichi Yamashita

doi:10.1507/endocrj.EJ12-0070

ORIGINALS

Surgical management of primary thyroid carcinoma arising in thyroglossal duct cyst: An experience of a single institution in Serbia

Radan Dzodic, Ivan Markovic, Boban Stanojevic, Vladimir Saenko, Marko Buta, Igor Djurisic, Merima Oruci, Gordana Pupic, Zorka Milovanovic, Shunichi Yamashita

Author information

Radan Dzodic
School of Medicine University of Belgrade, Serbia
Institute of oncology and radiology of Serbia, Surgical Oncology Clinic, Serbia
Ivan Markovic
School of Medicine University of Belgrade, Serbia
Institute of oncology and radiology of Serbia, Surgical Oncology Clinic, Serbia
Boban Stanojevic
Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
University of Belgrade, Institute for Nuclear Science “Vinca,” Belgrade, Serbia
Vladimir Saenko
Department of Health Risk Control, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Marko Buta
Institute of oncology and radiology of Serbia, Surgical Oncology Clinic, Serbia
Igor Djurisic
Institute of oncology and radiology of Serbia, Surgical Oncology Clinic, Serbia
Merima Oruci
Institute of oncology and radiology of Serbia, Surgical Oncology Clinic, Serbia
Gordana Pupic
Institute of oncology and radiology of Serbia, Department of Pathology, Serbia
Zorka Milovanovic
Institute of oncology and radiology of Serbia, Department of Pathology, Serbia
Shunichi Yamashita
Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Keywords: Thyroglossal duct cyst carcinoma, Surgical strategy, Lymph node dissection, Synchronous thyroid carcinoma

JOURNAL FREE ACCESS

2012 Volume 59 Issue 6 Pages 517-522

DOI https://doi.org/10.1507/endocrj.EJ12-0070

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Abstract

Thyroglossal duct cyst (TDC) carcinoma is a comparable rare entity and treatment strategies have not been standardized. Here, we report a favorable outcome of TDC carcinoma patients based on our therapeutic strategy. Twelve patients with TDC carcinoma treated in our department from 1986 to 2012 were enrolled. Ten patients underwent Sistrunk’s procedure in other institutions and referred to our institution for re-operation after the diagnosis of TDC carcinoma and the remaining two underwent initial surgery in our institution. Eleven patients were diagnosed as papillary and one as follicular carcinoma originating from TDC. We performed total thyroidectomy for 11, and limited thyroidectomy for one patient. Three patients (25%) had carcinoma lesions in the thyroid. We routinely dissected level I bilaterally and 6 of 11 patients (55%) with papillary carcinoma-type TDC carcinoma had metastasis. Level II/III nodes were biopsied and if positive, we performed level II-IV dissection. Of the 5 patients positive for level II/III, 2 were also positive for level IV. For the 3 patients with synchronous carcinoma in the thyroid, we performed level VI dissection and two had metastasis in this level. To date, 1 patient showed a recurrence to the lung, but none of the patients in our series died of carcinoma. For surgery of TDC carcinoma, Sistrunk’s procedure, total thyroidectomy with level I dissection is mandatory. Whether level II-IV dissection is performed depends on pathology of biopsied level II/III nodes. Level VI dissection is also recommended especially when carcinoma lesions are pre/intra operatively detected in the thyroid.

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