Inflammatory pseudotumor-like follicular dendritic cell sarcoma: clinicopathological features and prognosis study of 6 casesChinese Full Text
XIANG Chun-xiang;WANG Jian-jun;WU Nan;YU Bo;XIA Chun;HE Yan;MA Jie;SHI Qun-li;Department of Pathology,Nanjing General Hospital of Nanjing Military Command;Department of Pathology,Wuhan Central Hospital;
Abstract: Purpose To explore the clinicopathological features of inflammatory pseudotumor-like follicular dendrtic cell sarcoma（ IPT-like FDCS）. Methods Six patients diagnosed with IPT-like FDCS were retrospectively observed and analyzed by means of clinicopathological data,immunohistochemical staining and in situ hybridization for Epstein-Barr virus（ EBV）-encoded RNA（ EBER）.Results Among the 6 cases diagnosed as IPT-like FDCS,four cases were female,two cases were male,aged from 40 to 78 years（ mean 62.3 years）. The clinical symptoms were non-specific,which four cases were documented by physical examination,one had abdominal distension and emaciation,and one had low back pain with the tumor in the retroperitoneal. The neoplasms,with a mean size 7. 8 cm（ range,3. 5 to 14 cm）,occurred in the spleen（ three cases）,liver（ two cases） and retroperitoneal（ one case）,which were usually slow-growing. The neoplasms usually had well-defined borders,composed of round,oval and spindle cells. The optical management of dysplasia were not obvious and they were arranged in whorls and a spiral or storiform growth pattern,mixed with inflammatory cells. Immunohistochemically,tumor cells were positive for CD21 /35,vimentin and Clusterin protein,with EBER in situ hybridization scattered positive. All cases went complete surgical excision of tumors and were followed up for 3 48 months,with 5 patients disease-free and 1 patient lost follow-up（ disease-unknown）. Conclusions IPT-like FDCS is a rare low-grade malignant tumor associated with EBV infection with a relatively indolent biological behavior,which is female predominated and mainly occurs in spleen and liver,and complete surgical excision may be the optimal approach to be performed.
- DOI：
10.13315/j.cnki.cjcep.2014.07.012
- Series：
- Subject：
- Classification Code：
R735.2
- Mobile Reading
Read on your phone instantly
Step 1Scan QR Codes
"Mobile CNKI-CNKI Express" App
Step 2Open“CNKI Express”
and click the scan icon in the upper left corner of the homepage.
Step 3
Scan QR Codes
Read this article on your phone.
- HTML
- CAJ Download
- PDF Download
Download the mobile appuse the app to scan this coderead the article.
Tips: Please download CAJViewer to view CAJ format full text.
Download: 290 Page: 751-754 Pagecount: 4 Size: 335K
Citation Network
Related Literature
- Similar Article
- Reader Recommendation
- Associated Author