miR-9 gene expression in esophageal cancer tissues and noncancerous tissues surrounding esophageal cancerChinese Full Text
FENG Ju-bin;ZHANG Gui-yan;MAI Guan-liang;YANG Song-hai;CHEN Shu-zhen;Department of Gastroenterology,Zhong-cun Hospital of PanYu District;Integrated Department,Central Hospital of Panyu District;Department of Gastroenterology,the First People’s Hospital of Guangzhou;
Abstract: Objective:To investigate the differential expression of miR-9in esophageal cancer tissues and noncancerous tissues.Methods:The expression of miR-9in both esophageal cancer and adjacent non-tumour tissues was quantified with SYBR GreenⅠbased qRT-PCR according to the formula of 2-ΔΔCT.The potential target genes of miR-9were predicted by TargetScan5.2,MiRanda,PITA,PicTar. Results:The expression of miR-9was significantly down-regulated in esophageal cancer tissues than their adjacent non-tumour tissues（P＜0.05）,which was correlated with lumph node metastasis（P＜0.05）,but not significantly correlated with other clinicopathologic parameters,including age,gender,histological type and clinical stage.GOLPH3,RAB34and ALCAM were confirmed as direct targets of miR-9.Conclusions:Lower-expression of miR-9in esophageal cancer is correlated with pathogenesis of esophageal cancer,which is related to lymph node metastasis.
- DOI：
10.13210/j.cnki.jhmu.20131228.023
- Series：
- Subject：
- Classification Code：
R735.1
- Mobile Reading
Read on your phone instantly
Step 1Scan QR Codes
"Mobile CNKI-CNKI Express" App
Step 2Open“CNKI Express”
and click the scan icon in the upper left corner of the homepage.
Step 3
Scan QR Codes
Read this article on your phone.
- HTML
- CAJ Download
- PDF Download
Download the mobile appuse the app to scan this coderead the article.
Tips: Please download CAJViewer to view CAJ format full text.
Download: 124 Page: 458-461+464 Pagecount: 5 Size: 914K
Citation Network
Related Literature
- Similar Article
- Reader Recommendation
- Associated Author