Clinical Presentation, Management and Outcome of Japanese Patients With Acute Myocardial Infarction in the Troponin Era　– Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) –

Masaharu Ishihara; Masashi Fujino; Hisao Ogawa; Satoshi Yasuda; Teruo Noguchi; Koichi Nakao; Yukio Ozaki; Kazuo Kimura; Satoru Suwa; Kazuteru Fujimoto; Yasuharu Nakama; Takashi Morita; Wataru Shimizu; Yoshihiko Saito; Kennichi Tsujita; Kunihiko Nishimura; Yoshihiro Miyamoto; on behalf of the J-MINUET investigators

doi:10.1253/circj.CJ-15-0217

Late Breaking Cohort Studies (JCS 2015)

Clinical Presentation, Management and Outcome of Japanese Patients With Acute Myocardial Infarction in the Troponin Era　– Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) –

Masaharu Ishihara, Masashi Fujino, Hisao Ogawa, Satoshi Yasuda, Teruo Noguchi, Koichi Nakao, Yukio Ozaki, Kazuo Kimura, Satoru Suwa, Kazuteru Fujimoto, Yasuharu Nakama, Takashi Morita, Wataru Shimizu, Yoshihiko Saito, Kennichi Tsujita, Kunihiko Nishimura, Yoshihiro Miyamoto, on behalf of the J-MINUET investigators

Author information

Masaharu Ishihara
Division of Coronary Artery Disease, Department of Internal Medicine, Hyogo College of Medicine
Masashi Fujino
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
Hisao Ogawa
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
Department of Cardiovascular Medicine, Graduate School of Medical Science, Kumamoto University
Satoshi Yasuda
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
Teruo Noguchi
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
Koichi Nakao
Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center
Yukio Ozaki
Department of Cardiology, Fujita Health University Hospital
Kazuo Kimura
Division of Cardiology, Yokohama City University Medical Center
Satoru Suwa
Department of Cardiology, Juntendo University Shizuoka Hospital
Kazuteru Fujimoto
Department of Cardiology, National Hospital Organization Kumamoto Medical Center
Yasuharu Nakama
Department of Cardiology, Hiroshima City Hospital
Takashi Morita
Division of Cardiology, Osaka General Medical Center
Wataru Shimizu
Division of Cardiology and Regenerative Medicine, Nippon Medical School
Yoshihiko Saito
First Department of Medicine, Nara Medical University
Kennichi Tsujita
Department of Cardiovascular Medicine, Graduate School of Medical Science, Kumamoto University
Kunihiko Nishimura
Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center
Yoshihiro Miyamoto
Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center
on behalf of the J-MINUET investigators

Keywords: Acute myocardial infarction, Japan, Mortality, Troponin

JOURNAL FREE ACCESS FULL-TEXT HTML

2015 Volume 79 Issue 6 Pages 1255-1262

DOI https://doi.org/10.1253/circj.CJ-15-0217

CORRIGENDUM (79-7 pp. 1643)

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Abstract

Background:New criteria for diagnosis of acute myocardial infarction (AMI) were proposed in 2000 as a universal definition, in which cardiac troponin (cTn) was the preferred biomarker. A large number of patients formerly classified by creatine kinase (CK) as unstable angina are now ruled-in by cTn as non-ST-elevation myocardial infarction (NSTEMI).Methods and Results:The Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET) is a prospective and multicenter registry conducted in 28 institutions. We enrolled 3,283 consecutive patients with AMI diagnosed by cTn-based criteria who were admitted to participating institutions within 48 h of symptom onset. There were 2,262 patients (68.9%) with STEMI and 1,021 (31.1%) with NSTEMI. CK was not elevated more than twice the upper limit of normal in 458 patients (44.9%) with NSTEMI (NSTEMI-CK). Although there was no significant difference in the in-hospital mortality of STEMI and NSTEMI with CK elevation (NSTEMI+CK) patients (7.1% vs. 7.8%, P=0.57), it was significantly lower in patients with NSTEMI-CK than in those with STEMI or NSTEMI+CK (1.7%, P<0.001 for each).Conclusions:J-MINUET revealed the clinical presentation, management and outcomes of Japanese patients with AMI in the current cTn era. We should be aware of the difference between AMI diagnosed by CK-based criteria and AMI diagnosed by cTn-based criteria when using universal definitions for the diagnosis of AMI. (Circ J 2015; 79: 1255–1262)

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