Potent Capillary Isotachophoresis (cITP) for Analyzing a Marker of Coronary Heart Disease Risk and Electronegative Low-Density Lipoprotein (LDL) in Small Dense LDL Fraction

Keita Noda; Bo Zhang; Yoshinari Uehara; Shin-ichiro Miura; Akira Matsunaga; Keijiro Saku

doi:10.1253/circj.69.1568

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Potent Capillary Isotachophoresis (cITP) for Analyzing a Marker of Coronary Heart Disease Risk and Electronegative Low-Density Lipoprotein (LDL) in Small Dense LDL Fraction

Keita Noda, Bo Zhang, Yoshinari Uehara, Shin-ichiro Miura, Akira Matsunaga, Keijiro Saku

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Keywords: Capillary isotachophoresis (cITP), Electronegative low-density lipoprotein (LDL), Small dense LDL

JOURNAL FREE ACCESS

2005 Volume 69 Issue 12 Pages 1568-1570

DOI https://doi.org/10.1253/circj.69.1568

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Abstract

Background The potency and usefulness of capillary isotachophoresis (cITP) for assessing whole-serum lipoprotein profiles and quantifying electronegative low-density lipoprotein (LDL) has been previously reported. Methods and Results A new cITP method to measure electronegative LDL in the small dense LDL fraction has been established. Both electronegative LDL and electronegative LDL in the small dense LDL fraction decreased after treatment with fenofibrate. Conclusions This method appears to be useful for analyzing a marker of coronary heart disease risk and may be suitable for evaluating the effects of hypolipidemic agents. (Circ J 2005; 69: 1568 - 1570)

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