Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Valvular Heart Disease
Transcatheter Aortic Valve Implantation vs. Surgical Aortic Valve Replacement for Severe Aortic Stenosis in Real-World Clinical Practice
Yasuaki Takeji, Tomohiko Taniguchi, Takeshi Morimoto, Naritatsu Saito, Kenji Ando, Shinichi Shirai, Genichi Sakaguchi, Yoshio Arai, Yasushi Fuku, Yuichi Kawase, Tatsuhiko Komiya, Natsuhiko Ehara, Takeshi Kitai, Tadaaki Koyama, Shin Watanabe, Hirotoshi Watanabe, Hiroki Shiomi, Eri Minamino-Muta, Shintaro Matsuda, Hidenori Yaku, Yusuke Yoshikawa, Kazuhiro Yamazaki, Masahide Kawatou, Kazuhisa Sakamoto, Toshihiro Tamura, Makoto Miyake, Hisashi Sakaguchi, Koichiro Murata, Masanao Nakai, Norio Kanamori, Chisato Izumi, Hirokazu Mitsuoka, Masashi Kato, Yutaka Hirano, Tsukasa Inada, Kazuya Nagao, Hiroshi Mabuchi, Yasuyo Takeuchi, Keiichiro Yamane, Takashi Tamura, Mamoru Toyofuku, Mitsuru Ishii, Moriaki Inoko, Tomoyuki Ikeda, Katsuhisa Ishii, Kozo Hotta, Toshikazu Jinnai, Nobuya Higashitani, Yoshihiro Kato, Yasutaka Inuzuka, Yuko Morikami, Kenji Minatoya, Takeshi Kimura, on behalf of the CURRENT AS Registry Investigators and K-TAVI Registry Investigators
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Keywords: Aortic stenosis, Surgical aortic valve replacement, Transcatheter aortic valve implantation
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Supplementary material

2020 Volume 84 Issue 5 Pages 806-814

Editorial (84-5 pp. 704-705)
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Abstract

Background:There are no data comparing transcatheter aortic valve implantation (TAVI) with surgical aortic valve replacement (SAVR) outcomes in real clinical practice in Japan.

Methods and Results:We combined 2 independent registries, the K-TAVI Registry (a 6-center prospective registry of consecutive patients who underwent TAVI) and the CURRENT AS Registry (a large, 27-center registry of 3,815 consecutive patients with severe aortic stenosis [AS]). In the K-TAVI Registry, 338 patients underwent TAVI with SAPIEN XT balloon-expandable valves from October 2013 to January 2016, whereas in the CURRENT AS Registry 237 patients with severe AS underwent SAVR from January 2003 to December 2011. Propensity score matching was conducted, with final cohort comprising 306 patients. The cumulative 2-year incidence of all-cause death and heart failure (HF) hospitalization did not differ significantly between the TAVI and SAVR groups (13.7% vs. 12.4% [P=0.81] and 7.9% vs 3.9% [P=0.13], respectively). After adjusting for residual confounders, there were no significant differences between the TAVI and SAVR groups in the risk for all-cause death (hazard ratio [HR] 0.74; 95% confidence interval [CI] 0.35–1.58; P=0.43) or HF hospitalization (HR 1.27; 95% CI 0.40–4.59; P=0.69).

Conclusions:These findings from 2 independent Japanese registries suggest that the 2-year risk of all-cause mortality and HF does not differ significantly between TAVI and SAVR groups in real-world practice in Japan.

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© 2020 THE JAPANESE CIRCULATION SOCIETY
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