Thalidomide as a Nitric Oxide Synthase Inhibitor and Its Structural Development

Rumiko Shimazawa; Hiroko Sano; Aya Tanatani; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1248/cpb.52.498

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Thalidomide as a Nitric Oxide Synthase Inhibitor and Its Structural Development

Rumiko Shimazawa, Hiroko Sano, Aya Tanatani, Hiroyuki Miyachi, Yuichi Hashimoto

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Keywords: thalidomide, nitric oxide synthase (NOS), inhibitor, structural development

JOURNAL FREE ACCESS

2004 Volume 52 Issue 4 Pages 498-499

DOI https://doi.org/10.1248/cpb.52.498

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Abstract

Thalidomide has been found to exhibit weak nitric oxide synthase (NOS)-inhibitory activity. Structural development studies of thalidomide showed that some N-2,6-dimethylphenylhomophthalimide analogs possess NOS-inhibiting activity.

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