YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ノート
危険ドラッグ吸入曝露試験の開発
猪又 明子, 小縣 昭夫, 多田 幸恵, 長澤 明道, 湯澤 勝廣, 安藤 弘, 久保 喜一, 高橋 博, 海鉾 藤文, 田中 和良, 中嶋 順一, 鈴木 淳子, 植村 望美, 守安 貴子, 渡辺 大介, 石原 恵, 宇佐美 孝, 亀井 学, 河野 安昭
著者情報
キーワード: inhalation exposure, neuro-behavioral observation, synthetic cannabimimetics, mouse
ジャーナル フリー

2017 年 137 巻 8 号 p. 1005-1015

詳細
PDFをダウンロード (691K)
メタデータをダウンロード RIS形式

(EndNote、Reference Manager、ProCite、RefWorksとの互換性あり)

BIB TEX形式

(BibDesk、LaTeXとの互換性あり)

テキスト
メタデータのダウンロード方法
発行機関連絡先
抄録

 We developed a new inhalation exposure method to evaluate effects of synthetic cannabimimetics that are being distributed as new, unregulated drugs in the Tokyo area. We selected the commercial product “SOUTOU” containing AB-CHMINACA and 5F-AMB as the test drug and dried marshmallow (Althaea officinalis) leaves as the negative control. A half cigarette packed with dried marshmallow leaves or SOUTOU was ignited, then mainstream smoke from each was delivered to five mice in an exposure box. After the cigarettes were fully consumed, neurobehavioral observations and a catalepsy test were performed at 15, 30 and 60 min after exposure. The effluent air from the exposure box was poured into impingers containing acetonitrile (first impinger) and dimethyl sulfoxide (second impinger). The resulting solutions were analyzed to assess decomposition of the synthetic cannabimimetics. Mice exposed to SOUTOU smoke showed many excitement behaviors and some suppressive behaviors at 15, 30 and 60 min. These clearly included cannabimimetic specific pharmacological actions. Negative control mice also showed some suppressive behaviors at 15 min but these were attenuated at later times, nearly disappearing at 60 min. In addition, the behavioral effects observed in controls were less pronounced than those in SOUTOU exposed mice. The inhalation exposure method developed in our study would be effective for determining cannabinoid specific pharmacological effects of illegal drugs, as well as for assessing the presence of active compound(s) by comparing the test substance with a negative control.

著者関連情報
© 2017 The Pharmaceutical Society of Japan
前の記事 次の記事
お気に入り & アラート

閲覧履歴
前身誌

藥學雜誌

薬学雑誌. 甲號

薬学雑誌. 乙号

このページを共有する
feedback
 Top