Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Cyclic Sulfoxides-Garlicnins K1, K2, and H1-Extracted from Allium sativum
Toshihiro Nohara , Yukio Fujiwara, Yusuke Komota, Yoshihiko Kondo, Taiki Saku, Koki Yamaguchi, Yoshihiro Komohara, Motohiro Takeya
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Keywords: Allium sativum, cyclic sulfoxide, garlicnin K, tetrahydrothiophen derivative, M2 activated macrophage, anticancer activity
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2015 Volume 63 Issue 2 Pages 117-121

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Abstract

Newly identified cyclic sulfoxides—garlicnins K1 (1), K2 (2), and H1 (3)—were isolated from the acetone extracts of the bulbs of garlic, Allium sativum. Garlicnin H1 (3) demonstrated potential to suppress tumor cell proliferation by regulating macrophage activation. The structures of garlicnins K1 and K2, 3,4-dimethyl-5-allyl-tetrahydrothiophen-2-one-S-oxides, and the structure of garlicnin H1, 3-carboxy-3-hydroxy-4-methyl-5-allylsulfoxide-tetrahydrothiophen-2-(ethane-1,2-diol)-S-oxide were characterized by spectroscopic analysis.

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© 2015 The Pharmaceutical Society of Japan
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