Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Aldose Reductase Inhibitors from Natural Products. II. : Active Components of a Paraguayan Crude Drug "Para-parai mi, " Phyllanthus niruri
Mineo SHIMIZU, Syunji HORIE, Satoshi TERASHIMA, Hajime UENO, Toshimitsu HAYASHI, Munehisa ARISAWA, Shoichi SUZUKI, Masao YOSHIZAKI, Naokata MORITA
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Keywords: Phyllanthus niruri, Euphorbiaceae, aldose reductase inhibitor, ellagic acid, brevifolin carboxylic acid, ethyl brevifolin carboxylate
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1989 Volume 37 Issue 9 Pages 2531-2532

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Abstract

Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mi, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR.

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