From an ethyl acetate extract of the root bark of cultivated mulberry tree (Morus Lhou (ser.) Koidz.), a 2-arylbenzofuran derivative was isolated and named mulberrofuran H. Its structure was shown to be 1 on the basis of spectral evidence. Mulberrofuran H is regarded biogenetically as a variation of a Diels-Alder type adduct of a chalcone derivative and a dehydroprenyl-2-arylbenzofuran derivative.