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J Brachial Plex Peripher Nerve Inj 2009; 04(01): e29-e35
DOI: 10.1186/1749-7221-4-6
Research article
Kalender et al; licensee BioMed Central Ltd.

Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model[*]

Ali Murat Kalender
1   Department of Orthopedics and Traumatology, Kahramanmaras Sutcu Imam University, Medical Faculty, K. Maras, Turkey
,
Ali Dogan
2   Department of Orthopedics and Traumatology, Yuzuncu Yil University, Medical Faculty, Van, Turkey
,
Vedat Bakan
3   Department of Pediatric Surgery, Kahramanmaras Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey
,
Huseyin Yildiz
4   Department of Anesthesiology and Reanimation, Kahramanmaras Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey
,
Mehmet Ata Gokalp
2   Department of Orthopedics and Traumatology, Yuzuncu Yil University, Medical Faculty, Van, Turkey
,
Mahmut Kalender
5   Gaziantep Medical Center, Gaziantep, Turkey
› Author Affiliations
Subject Editor:
Further Information

Publication History

22 April 2009

09 June 2009

Publication Date:
18 September 2014 (online)

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Abstract

Background Zofenopril is an antioxidant agent which has been shown to have beneficial effects in hypertension and heart failure. The aim of this study was to test the effects of Zofenopril on nerve regeneration and scarring in a rat model of peripheral nerve crush injury.

Methods Twenty-one adult Sprague-Dawley rats underwent a surgical procedure involving right sciatic nerve crush injury. 15 mg/kg Zofenopril was administered orally to seven rats in group Z for seven days. Seven rats in group S received saline orally for seven days. Seven rats in the control group C received no drug after crush injury. Fourteenth and 42nd days after injury, functional and electromyography assessments of nerves were performed. Functional recovery was analyzed using a walking track assessment, and quantified using the sciatic functional index (SFI). After these evaluations, all rats were sacrificed and microscopic evaluations were performed.

Results The Sciatic functional Index (SFI) in group Z on 14th day is different significantly from group S and group C (p = 0.037). But on 42nd day there was no difference between groups (p = 0.278). The statistical analyses of electromyelographic (EMG) studies showed that the latency in group Z is significantly different from group S (p = 0.006) and group C (p = 0.045). But on 42nd day there was no difference between groups like SFI (p = 0.147). The amplitude was evaluated better in group Z than others (p < 0.05). In microscopic evaluation, we observed the highest number of nerve regeneration in the group Z and the lowest in the group C. But it was not significant statistically.

Conclusion Our results demonstrate that Zofenopril promotes the regeneration of peripheral nerve injuries in rat models.

* This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


 

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