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Thromb Haemost 2013; 110(04): 742-750
DOI: 10.1160/TH13-03-0242
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Genetic association of five plasminogen activator inhibitor-1 (PAI-1) polymorphisms and idiopathic recurrent pregnancy loss in Korean women

Young Joo Jeon   *
1   Institute for Clinical Research, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea
,
Young Ran Kim   *
2   Department of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea
,
Bo Eun Lee
1   Institute for Clinical Research, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea
,
Yi Seul Choi
1   Institute for Clinical Research, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea
,
Ji Hyang Kim
2   Department of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea
,
Ji Eun Shin
2   Department of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea
,
HyungChul Rah
1   Institute for Clinical Research, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea
,
Sun Hee Cha
2   Department of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea
,
Woo Sik Lee
3   Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, South Korea
,
Nam Keun Kim
1   Institute for Clinical Research, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam, South Korea
› Author Affiliations Financial Support: This study was partially supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, South Korea (A120080) and partially supported by National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093821 & NRF-2012R1A1A2007033).
Further Information

Publication History

Received: 19 March 2013

Accepted after major revision: 03 July 2013

Publication Date:
01 December 2017 (online)

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Erratum to Jeon et al. "Genetic association of five plasminogen activator inhibtitor-1 (PAI-1) polymorphsms and idiopathic recurrent pregnancy loss in Korean women" (Thromb Haemost 2013; 110: 742-750)Thromb Haemost 2013; 110(12): 1307
DOI: 10.1160/TH13120001

Summary

Plasminogen activator inhibitor-1 (PAI-1) is important for maintaining pregnancy. Aberrantly increased PAI-1 levels may contribute to thrombosis and inflammation, leading to pregnancy loss. This study investigated the association of PAI-1 polymorphisms (PAI-1 rs2227631 [-844G>A], rs1799889 [-675 4G/5G], rs6092 [43G>A], rs2227694 [9785G>A], and rs7242 [11053T>G]) with idiopathic recurrent pregnancy loss (RPL) in Korean women. We screened 308 RPL patients and 227 control participants for five PAI-1 polymorphisms. Genotyping of PAI-1 was performed by polymerase chain reaction-restriction fragment length polymorphism assay. PAI-1 4G4G and -844AA/ 4G4G/11053GG genotypes were associated with RPL. PAI-1 -844A/4G/43G/9785G/11053G haplotype was connected to hypofibrinolytic status (i.e. increased levels of plasma PAI-1, increased numbers of platelets, reduced prothrombin time, and reduced activated partial thromboplastin time). Moreover, PAI-1 11053TG+GG frequency was positively related to plasma homocysteine and urate levels, whereas -844AA frequency was associated with plasma folate concentrations according to ordinal logistic regression analysis. Based on these results, we propose that PAI-1 -844G>A, 4G/5G, and 11053T>G polymorphisms are markers of RPL.

Keywords

Plasminogen activator inhibitor-1 - polymorphism - recurrent pregnancy loss

* Young Joo Jeon and Young Ran Kim contributed equally to this work.


 

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