Kansenshogaku Zasshi
Online ISSN : 1884-569X
Print ISSN : 0387-5911
ISSN-L : 0387-5911
Clinical Studies of Sixteen Cases with Pulmonary Cryptococcosis Mainly with
Respect to Serum Level of Cryptococcal Antigen
Yasumasa DOHTSU, Yuji ISHIMATSU, Hiroshi TAKATANI, Kazunori MINAMI, Keiji INOUE, Norihiro KOHARA, Katsunori YANAGIHARA, Yasuhito HIGASHIYAMA, Yoshitsugu MIYAZAKI, Yoichi HIRAKATA, Shigeru KOHNO
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Keywords: Cryptococcus, antigen
JOURNAL FREE ACCESS

2005 Volume 79 Issue 9 Pages 656-663

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Abstract

Clinical studies of sixteen cases with pulmonary cryptococcosis, during the past six years between 1998 and 2004, were peformed mainly with respect to serum cryptococcal antigen titer. Serum cryptococcal antigen was positive in twelve of 16 cases, the other three cases were diagnosed by VATS, the other one by positive culture of cryptococcus in BALF. In these twelve cases, the serum cryptococcal antigen titer was continuously tested after treatment. The serum cryptococcal antigen titer decreased from half to 6 months after treatment. And the cryptococcal Ag changed to negative in six of the 12 cases by antifungal agents from 5 to 19 months. But four cases whose pneumonia was severe tended to have a high titer level of cryptococcal antigen and were positive for a long period. In the Chest CT of four pulmonary cryptococcosis case with negative cryptococcal antigen, all of the maximum nodule size was less than or equal to 15mm in diameter.

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