びまん性汎細気管支炎に対するazithromycinの臨床的検討

小林 宏行; 武田 博明; 酒寄 享; 川上 義和; 大塚 義紀; 田村 昌士; 小西 一樹; 谷本 普一; 深草 元紀; 島田 馨; 佐野 靖之; 荒井 康男; 宍戸 春美; 渡辺 尚; 坂本 恵理子; 中田 紘一郎; 中谷 龍王; 坪井 永保; 小田切 繁樹; 鈴木 周雄; 吉池 保博; 平居 義裕; 大久保 隆男; 池田 大忠; 荒川 正昭; 和田 光一; 塚田 弘樹; 佐藤 篤彦; 千田 金吾; 成田 亘啓; 澤木 政好; 三笠 桂一; 副島 林造; 二木 芳人; 沖本 二郎; 佐々木 孝夫; 松本 行雄; 杉本 勇二; 城戸 優光; 二階堂 義彦; 荒川 規矩男; 向野 賢治; 石橋 凡雄; 高本 正祇; 北原 義也; 原 耕平; 河野 茂; 門田 淳一; 那須 勝; 後藤 陽一郎; 山崎 透; 斎藤 厚; 普久原 浩; 稲留 潤

doi:10.11150/kansenshogakuzasshi1970.69.711

Study on Azithromycin in Treatment of Diffuse Panbronchiolitis

Hiroyuki KOBAYASHI, Hiroaki TAKEDA, Susumu SAKAYORI, Yoshikazu KAWAKAMI, Yoshinori OTSUKA, Masashi TAMURA, Kazuki KONISHI, Shinichi TANIMOTO, Motonori FUKAKUSA, Kaoru SHIMADA, Yasuyuki SANO, Yasuo ARAI, Harumi SHISHIDO, Hisashi WATANABE, Eriko SAKAMOTO, Koichiro NAKATA, Tatsuo NAKATANI, Nagayasu TSUBOI, Shigeki ODAGIRI, Kaneo SUZUKI, Yasuhiro YOSHIIKE, Yoshihiro HIRAI, Takao OKUBO, Hirotada IKEDA, Masaaki ARAKAWA, Kouichi WADA, Hiroki TSUKADA, Atsuhiko SATO, Kingo CHIDA, Nobuhiro NARITA, Masayoshi SAWAKI, Keiichi MIKASA, Rinzo SOEJIMA, Yoshihito NIKI, Niro OKIMOTO, Takao SASAKI, Yukio MATSUMOTO, Yuji SUGIMOTO, Masamitsu KIDO, Yoshihiko NIKAIDO, Kikuo ARAKAWA, Kenji KOHNO, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Yoshinari KITAHARA, Kohei HARA, Shigeru KOHNO, Junichi KADOTA, Masaru NASU, Yoichiro GOTO, Tohru YAMASAKI, Atsushi SAITO, Hiroshi FUKUHARA, Jun INADOME

Author information

Hiroyuki KOBAYASHI
First Department of Internal Medicine, Kyorin University School of Medicine
Hiroaki TAKEDA
First Department of Internal Medicine, Kyorin University School of Medicine
Susumu SAKAYORI
First Department of Internal Medicine, Kyorin University School of Medicine
Yoshikazu KAWAKAMI
First Department of Medicine, Hokkaido University, School of Medicine
Yoshinori OTSUKA
First Department of Medicine, Hokkaido University, School of Medicine
Masashi TAMURA
Third Department of Internal Medicine, Iwate Medical University
Kazuki KONISHI
Third Department of Internal Medicine, Iwate Medical University
Shinichi TANIMOTO
Department of Internal Medicine, IV, The Jikei University School of Medicine
Motonori FUKAKUSA
Department of Internal Medicine, IV, The Jikei University School of Medicine
Kaoru SHIMADA
Department of Infectious Diseases, Institute of Medical Science, The University of Tokyo
Yasuyuki SANO
Division of Allergy and Respiratory Diseases, Doai Memorial Hospital
Yasuo ARAI
Division of Allergy and Respiratory Diseases, Doai Memorial Hospital
Harumi SHISHIDO
Department of Respiratory Diseases, Tokyo National Chest Hospital
Hisashi WATANABE
Department of Respiratory Diseases, Tokyo National Chest Hospital
Eriko SAKAMOTO
Department of Respiratory Diseases, Tokyo National Chest Hospital
Koichiro NAKATA
Department of Respiratory Diseases, Toranomon Hospital
Tatsuo NAKATANI
Department of Respiratory Diseases, Toranomon Hospital
Nagayasu TSUBOI
Department of Respiratory Diseases, Toranomon Hospital
Shigeki ODAGIRI
Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
Kaneo SUZUKI
Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
Yasuhiro YOSHIIKE
Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
Yoshihiro HIRAI
Department of Respiratory Diseases, Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
Takao OKUBO
First Department of Internal Medicine, Yokohama City University School of Medicine
Hirotada IKEDA
First Department of Internal Medicine, Yokohama City University School of Medicine
Masaaki ARAKAWA
The Second Department of Internal Medicine, Niigata University, School of Medicine
Kouichi WADA
The Second Department of Internal Medicine, Niigata University, School of Medicine
Hiroki TSUKADA
The Second Department of Internal Medicine, Niigata University, School of Medicine
Atsuhiko SATO
Second Deprtment of Internal Medicine, Hamamatsu University School of Medicine
Kingo CHIDA
Second Deprtment of Internal Medicine, Hamamatsu University School of Medicine
Nobuhiro NARITA
Second Department of Internal Medicine, Nara Medical University
Masayoshi SAWAKI
Second Department of Internal Medicine, Nara Medical University
Keiichi MIKASA
Second Department of Internal Medicine, Nara Medical University
Rinzo SOEJIMA
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Yoshihito NIKI
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Niro OKIMOTO
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Takao SASAKI
Third Department of Internal Medicine, School of Medicine, Tottori University
Yukio MATSUMOTO
Third Department of Internal Medicine, School of Medicine, Tottori University
Yuji SUGIMOTO
Third Department of Internal Medicine, School of Medicine, Tottori University
Masamitsu KIDO
Department of Respiratory Diseases, University of Occupational and Environmental Health
Yoshihiko NIKAIDO
Department of Respiratory Diseases, University of Occupational and Environmental Health
Kikuo ARAKAWA
Second Department of Internal Medicine, School of Medicine Fukuoka University
Kenji KOHNO
Second Department of Internal Medicine, School of Medicine Fukuoka University
Tsuneo ISHIBASHI
Department of Internal Medicine, National Sanatorium Ohmuta Hospital
Masahiro TAKAMOTO
Department of Internal Medicine, National Sanatorium Ohmuta Hospital
Yoshinari KITAHARA
Department of Internal Medicine, National Sanatorium Ohmuta Hospital
Kohei HARA
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Shigeru KOHNO
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Junichi KADOTA
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Masaru NASU
Second Department of Internal Medicine, Oita Medical University
Yoichiro GOTO
Second Department of Internal Medicine, Oita Medical University
Tohru YAMASAKI
Second Department of Internal Medicine, Oita Medical University
Atsushi SAITO
First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Hiroshi FUKUHARA
First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
Jun INADOME
First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus

Keywords: azithromycin, diffuse panbronchiolitis, longterm chemotherapy

JOURNAL FREE ACCESS

1995 Volume 69 Issue 6 Pages 711-722

DOI https://doi.org/10.11150/kansenshogakuzasshi1970.69.711

Details

Abstract

In the treatment of diffuse panbronchiolitis, azithromycin (AZM), a new macrolide antibiotic with 15-membred lactone ring, was studied for its efficacy and safety.
AZM, 250 mg, was intermittently administered to a total of 60 patients twice a weeks, for 3 months as a rule, and its efficacy was clinically evaluated in 52 patients and the safety in 55.
The rate of efficacy was 84.6%(44/52). Clinical findings 12 weeks after the start of administration showed a decrease in sputum volume in 30 of 46 patients and amelioration of dyspnea on exertion in 23 of 46 patients, and no worsening of symptoms was observed in the patients. Vital capacity (4/22), FEVi.o (6/21), cold agglutination reaction (22/28), and CRP (16/36) were also improved. The rate of eradication of organisms isolated from the sputum except for indigenous organisms was 39.5%(15/38); 4 of the 22 strains of Pseudomonas aeruginosa were eradicated.
Adverse reactions were observed in 4 of the 55 patients (7.3%), 1 patient each with rash, itching, diarrhea, and a gastric symptom (heavy feeling in the stomach). 4 of the 54 patients (7.4%) exhibited abnormal changes in clinical laboratory test values. These were an increase in eosinophil count in 2, elevation of GOT in 1, and elevation of Al-P in 1. These adverse reactions and abnormal changes in laboratory test values were mild or moderate.
Therefore, long-term intermittent administration of AZM, twice a week, is expected to have the same effect in the treatment of diffuse panbronchiolitis as long-term small-dose administration of 14-membered macrolides such as erythromcin and clarithromycin, whose effects have already been established.

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