Accession Number	<strong>00001503-200410000-00014</strong>.
Author	Dabu-Bondoc, Susan M.
Institution	Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut, USA
Title	Regional anesthesia and perioperative outcome: what is new?[Miscellaneous]
Source	Current Opinion in Anaesthesiology. 17(5):435-439, October 2004.
Abstract	Purpose of review: This review of the most recent publications is aimed to look at the current developments regarding the effects of regional anesthesia on perioperative outcome. Recent findings: The debate continues on whether regional anesthesia and analgesia improve outcome or not. Researchers are still divided in their views. While previous meta-analyses are more favorable, more recent trials are rather on the con side. In an attempt to lessen heterogeneity, meta-analyses have now incorporated data from more recent trials to perform subgroup analyses. Such analyses persistently show the same positive results. The established outcome effects of regional anesthesia are mostly due its ability to provide superior analgesia, its ability to reduce the perioperative stress response and subsequent physiologic perturbations, and its ability to reduce pulmonary complications. Its potential to prevent cardiac morbidity in patients undergoing coronary artery bypass grafting is investigated further by looking at valuable specific biological markers like troponin I and natriuretric peptides. Intrathecal opioids do not seem to improve outcome, unlike the intrathecal local anesthetics. The latter improve outcome presumably by blocking the surgical stress response. In contrast, opioids, non-steriodal antiinflammatory drugs and cyclooxygenase-2 inhibitors have been shown not to impact outcome presumably by not being able to interfere with the stress response. The safety and efficacy of epidural or spinal anesthesia for spinal surgery continue to be demonstrated by current studies. Summary: Despite the controversies, the numerous potential benefits and advantages of regional anesthesia are keys to its continued popularity. With constant search for new scientific clues by improving experimental designs, valuable evidence slowly unfolds. Regional anesthesia certainly takes a leading role in the current trends for a multimodal approach of perioperative pain management. (C) 2004 Lippincott Williams & Wilkins, Inc.