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Relationship of vitamin E metabolism and oxidation in exercising human subjects

Published online by Cambridge University Press:  08 March 2007

Maret G. Traber
Maret G. Traber*
Affiliation:
Department of Nutrition and Exercise Sciences, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331-6512, USA
*
*Corresponding author:  Dr Maret G. Traber, fax +1 541 737 5077, email maret.traber@oregonstate.edu
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Abstract

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During endurance exercise, oxygen consumption by the skeletal muscle can increase 100–200 times. We previously found that during an ultramarathon race (50 km, forest trail through hilly terrain) compared with a day of rest, vitamin E disappeared faster (as measured using 2H-labelled α-tocopherol) and lipid peroxidation increased. Therefore, we hypothesized that prior supplementation with antioxidants (vitamins E and C) would decrease oxidative stress during distance running and, therefore, decrease lipid peroxidation and inflammation, decreaseDNA damage, decrease muscle damage and/or improve recovery. To test these hypotheses, we carried out a randomized, double-blind study in runners (n 11 females, 11 males) who were participants in an annual ultramarathon race. We found that supplementation with both vitamins E and C only prevented increases in lipid peroxidation, but had no apparent effect on DNA damage, inflammation or muscle damage. These results suggest that the mechanism of oxidative damage is operating independently of the inflammatory and muscle damage responses.

Keywords

Ultramarathonα-TocopherolCytokinesInflammationMuscle damageF2-isoprostanes
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue S1 , August 2006 , pp. S34 - S37
Copyright
Copyright © The Nutrition Society 2006

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