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Adaptation of urinary nitrogen excretion in infants to changes in protein intake

Published online by Cambridge University Press:  09 March 2007

H. Chan
H. Chan
Affiliation:
Medical Research Council, Tropical Metabolism Research Unit, University of the West Indies, Jamaica
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Abstract

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1. Thirty-six nitrogen-balance measurements were made on children recovering from malnutrition. Two types of diet were used: a high-protein diet providing from 1·25 to 6·0 g protein/kg per day which supported normal growth, and a low-protein diet providing 0·75 g protein/kg per day on which the children were approximately in N balance. Both diets provided 120 kcal/kg per day.

2. The size of the labile protein pool was estimated from the N lost on changing from a high- to a low-protein diet. After the change of diet a new equilibrium was reached in about 3 days.

3. Labile protein, as defined above, represented about 1·2% of the total body protein on changing from 6·0 to 0·75 g protein/kg per day, and about 0·2% of total body protein on changing from 1·5 to 0·75 g protein/kg per day. The magnitude of the labile protein pool did not appear to be related to the nutritional state of the child.

4. It is concluded that the labile protein pool is not a reservoir which can be filled, but that losses of N which occur on reducing the protein intake of an infant reflect a lag in metabolic adjustment.

Type
Research Article
Information
British Journal of Nutrition , Volume 22 , Issue 2 , May 1968 , pp. 315 - 323
Copyright
Copyright © The Nutrition Society 1968

References

Allison, J. B. (1950). In Symposia on Nutrition. Vol. 2. Plasma Proteins, p. 123. Springfield, Illinois: C. C. Thomas.Google Scholar
Allison, J. B. & Wannemacher, R. W. Jr (1965). Am. J. clin. Nutr. 16, 445.CrossRefGoogle Scholar
Allison, J. B., Wannemacher, R. W. Jr & Banks, W. L. Jr (1963). Fedn Proc. Fedn Am. Socs exp. Biol. 22, 1126.Google Scholar
Campbell, R. M. & Kosterlitz, H. W. (1948). Biochem. J. 43, 416.CrossRefGoogle Scholar
Chan, H. & Waterlow, J. C. (1966). Br. J. Nutr. 20, 775.CrossRefGoogle Scholar
Darrow, D. C. & Hellerstei, S. (1958). Physiol. Rev. 38, 114.CrossRefGoogle Scholar
Deuel, H. J. Jr, Sandiford, I., Sandiford, K. & Boothby, W. M. (1928). J. biol. Chem. 76, 391.Google Scholar
Fuhrman, F. A., Watson, J. L. & Crismon, J. M. (1951). Am. J. Physiol. 167, 305.CrossRefGoogle Scholar
Henry, K. M., Cormack, R. M. & Kosterlitz, H. W. (1961). Br. J. Nutr. 15, 199.CrossRefGoogle Scholar
Henry, K. M.Kosterlitz, H. W. & Quenouille, M. H. (1953). Br. J. Nutr. 7, 51.CrossRefGoogle Scholar
Martin, C. J. & Robison, R. (1922). Biochem. J. 16, 407.CrossRefGoogle Scholar
Munro, H. N. (1964). In Mammalian Protein Metabolism. Vol. 1, chapter 10. [Munro, H. N. and Allison, J. B. editors.] New York and London: Academic Press Inc.Google Scholar
Murlin, J. R., Edwards, L. E., Hawley, E. E. & Clark, L. C. (1946). J. Nutr. 31, 533.CrossRefGoogle Scholar
Nelson, W. E. (1959). Textbook of Pediatrics, 7th ed., p. 50. Philadelphia and London: W. B. Saunders Co.Google Scholar
Stearns, G., Newman, K. J., McKinley, J. B. & Jeans, P. C. (1958). Ann. N. Y. Acad. Sci. 69, 857.CrossRefGoogle Scholar
Swanson, P. (1959). In Protein and Amino Acid Nutrition. p. 195. [Albanese, A. A. editor.] New York: Academic Press Inc.Google Scholar
Thomas, K. (1910). Arch. Anat. Physiol., Physiol. Abt., Suppl-Band. 249.Google Scholar
Voit, C. (1866). Z. Biol. 2, 307.Google Scholar
Voit, C. (1867). Z. Biol. 3, 1.Google Scholar
Waterlow, J. C., Alleyne, G. A. O., Chan, H. V., Garrow, J. S., Hay, A., James, P., Picou, D. & Stephen, J. M. L. (1966). Archos lat.-am. Nutr. 16, 175.Google Scholar
Waterlow, J. C., Cravioto, J. & Stephen, J. M. L. (1960). Advanc. Protein Chem. 15, 131.CrossRefGoogle Scholar
Waterlow, J. C. & Wills, V. G. (1960). Br. J. Nutr. 14, 183.CrossRefGoogle Scholar
WHO (1965). Tech. Rep. Ser. Wld Hlth Org. no. 301.Google Scholar