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Horm Metab Res 1997; 29(11): 577-579
DOI: 10.1055/s-2007-979104
Originals Clinical

© Georg Thieme Verlag Stuttgart · New York

T3 Deficiency Prolongs Convulsions Induced by Acute Pentylenetetrazole

J. Pacheco-Rosado, L. Quevedo-Corona, S. R. Zamudio-Hernández, G. Chambert
  • Departamento de Fisiología “Mauricio Russek”. Escuela Nacional de Ciencias Biológicas, IPN, Carpio y Plan de Ayala, México
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Publication History

1996

1997

Publication Date:
23 April 2007 (online)

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The effects of 3,5,3'-triiodothyronine (T3) levels on threshold, latency and duration of pentylenetetrazole-induced seizures were tested in rats treated with thyroxine (300 µg/kg · day, N = 9) or methimazole (60 mg/kg · day, N = 5) dissolved in drinking water. Compared to controls (N = 7), methimazole treatment reduced T3 levels (45.4 ± 2.0 vs. 33.0 ± 4.8 ng/dl) and increased seizure duration (36.2 ± 22.4 vs. 289.6 ± 24.4 s) and threshold (29.0 ± vs. 45.5 mg/kg). Thyroxine treatment increased T3 levels (45.4 ± 2.0 vs. 67.7 ± 4.8 ng/dl), but had no significant effect on seizures.

Key words

Triiodothyronine - Thyroxine - Pentylenetetrazole - Seizures

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