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Horm Metab Res 2007; 39(5): 314-321
DOI: 10.1055/s-2007-976539
Special Topics Revisited

© Georg Thieme Verlag KG Stuttgart · New York

Endocrinology of Adipose Tissue - An Update

P. Fischer-Posovszky 1 , M. Wabitsch 1 , Z. Hochberg 2
  • 1Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany
  • 2Meyer Children's Hospital, Rambam Medical Center, and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Further Information

Publication History

received 8. 1. 2007

accepted 14. 2. 2007

Publication Date:
29 May 2007 (online)

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Abstract

Adipose tissue is the body's largest repository of energy and it plays an important role in total energy homeostasis. Moreover, it is now well recognized as an endocrine organ. A wide range of different factors including complex proteins as well as fatty acids, prostaglandins, and steroids are either synthesized de novo or converted in adipose tissue and released into the blood stream. These so-called adipokines contribute to the development of obesity-related disorders, particularly type-2 diabetes (T2D) and cardiovascular disease. In this review, we present an overview on the endocrine functions of adipose tissue with a special focus on discoveries reported within the past 5 years.

Key words

obesity - adipocyte - fat cell - SGBS cells - adiponectin - leptin - visfatin - RBP-4

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Correspondence

Prof. Dr. M. Wabitsch

Division of Pediatric Endocrinology and Diabetes

Department of Pediatrics and Adolescent Medicine

University of Ulm

Eythstr 24

89075 Ulm

Germany

Phone: +49/731/5002 77 15

Fax: +49/731/5002 67 14

Email: martin.wabitsch@uniklinik-ulm.de

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