Inhibitory Effect of Triterpenes from Crataegus pinatifida on HIV-I Protease

Byung Sun Min; Hyun Ju Jung; Jun Sung Lee; Young Ho Kim; Song Hae Bok; Chao Mei Ma; Norio Nakamura; Masao Hattori; Ki Hwan Bae

doi:10.1055/s-2006-960792

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Planta Med 1999; 65(4): 374-375
DOI: 10.1055/s-2006-960792

Letters

Inhibitory Effect of Triterpenes from Crataegus pinatifida on HIV-I Protease

Byung Sun Min¹ ^, ³ , Hyun Ju Jung¹ , Jun Sung Lee¹ , Young Ho Kim¹ , Song Hae Bok² , Chao Mei Ma³ , Norio Nakamura³ , Masao Hattori³ , KiHwan Bae¹

¹College of Pharmacy, Chungnam National University, Taejon 305-764, Korea
²Korea Research Institute of Bioscience & Biotechnology, Yusung, Taejon, Korea
³Research Institute for Traditional Sino-Japanese Medicines, Toyama Medical and Pharmaceutical University, Toyama, Japan

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Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100 µg/ml. The subsequent fractionation and isolation of the extract gave two active compounds. Their structures were identified as uvaol (1) and ursolic acid (2) by spectral data. These active compounds inhibit HIV-1 protease with IC₅₀ values of 5.5 and 8.0 µM, respectively.

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