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DOI: 10.1055/s-0029-1240634
© Georg Thieme Verlag KG Stuttgart · New York
Cytotoxic Lignan Esters from Cinnamomum osmophloeum
Publication History
received February 11, 2009
revised October 7, 2009
accepted October 24, 2009
Publication Date:
30 November 2009 (online)
Abstract
The bark and roots of Cinnamomum osmophloeum are widely used in Taiwan as spice substitutes for C. cassia. We have isolated three novel lignan esters, one dibenzylbutane-type ligan ester [9,9′-di-O-feruloyl-(+)-5,5′-dimethoxy secoisolariciresinol (3)] and two cyclolignan esters [(7′S,8′R,8R) ‐lyoniresinol-9-O-(E)-feruloyl ester (5) and (7′S,8′R,8R)-lyoniresinol-9,9′-di-O-(E)‐feruloyl ester (6)], and several known lignans from the heartwood and roots of C. osmophloeum. We identified these compounds using 1D and 2D NMR spectroscopy and mass spectrometry. Cytotoxicity assays of these novel lignan esters revealed that compound 6 has strong activities against human liver cancer (HepG2 and Hep3B) and oral cancer (Ca9-22) cells, with IC50 values of 7.87, 4.31, and 2.51 µg/mL, respectively.
Key words
Cinnamomum osmophloeum - Lauraceae - 9,9′‐di‐O‐feruloyl‐(+)‐5,5′‐dimethoxy secoisolariciresinol - (7′S,8′R,8R)‐lyoniresinol‐9‐O‐(E)‐feruloyl ester - (7′S,8′R,8R)‐lyoniresinol‐9,9′‐di‐O‐(E)‐feruloyl ester
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Prof. Ting-Ting Jong
Department of Chemistry
National Chung Hsing University
250 Kuo-Kuang Road
402 Taichung
Taiwan, R. O. C.
Phone: + 88 64 22 84 04 11 ext. 701
Email: ttjong@mail.nchu.edu.tw
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