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Horm Metab Res 1995; 27(3): 155-158
DOI: 10.1055/s-2007-979929
Originals Clinical

© Georg Thieme Verlag Stuttgart · New York

Increase in Urinary Calcium and Oxalate after Fructose Infusion

N. U. Nguyen, G. Dumoulin, M.-T. Henriet, J. Regnard
  • Explorations Fonctionnelles Rénales Métaboliques et Endocriniennes et Laboratoire de Physiologie, Centre Hospitalier Universitaire de Besançon, Besançon, France
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Publication History

1994

1994

Publication Date:
23 April 2007 (online)

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Abstract

We have previously shown that an oral glucose load increased both calciuria and oxaluria while the ingestion of fructose induced a rise in calciuria and a decrease in oxaluria. This latter effect remains unclear and might be linked to the reduced intestinal oxalate absorption subsequent to digestive intolerance in some subjects. Such a hypothesis could be enlightened by the study of a parenteral fructose load. Therefore in 7 healthy subjects, we compared the effects of fructose infusion (F) (15 min iv infusion at 0.185 mmol/kg BW/min) to a control glucose infusion (G) on urinary calcium and oxalate. In this study, glycemia and insulinemia increased less after (F) than after (G) (respectively + 21% vs + 216%, p < 0.001 and +230% vs +402%, p < 0.05) and phosphatemia decreased less after (F) than after (G) (-7% vs -14%, p < 0.05). Urinary calcium and oxalate increased only after (F) (respectively +64%, p < 0.01 and + 60%, p < 0.05). Urinary uric acid, another urolithiasis factor, increased after both (F) and (G) (respectively +45%; p < 0.01 and +42%; p < 0.01) but uricemia increased only after (F) (+25%; p < 0.01). Our results suggest an additional reason to avoid the use of fructose in parenteral nutrition, particularly in individuals with a known history of either calcium oxalate or urate urolithiasis.

Key words

Calcium - Oxalate - Urate - Fructose Infusion - Urolithiasis

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