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Horm Metab Res 1998; 30(2): 77-79
DOI: 10.1055/s-2007-978839
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© Georg Thieme Verlag Stuttgart · New York

AY-4166 Increases the Sensitivity of Insulin Secretion to Glucose in Isolated Perfused Rat Pancreas

S. Morimoto, O. Mokuda, Y. Sakamoto
  • Third Department of Internal Medicine, Teikyo University School of Medicine, Ichihara, Chiba, Japan
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Publication History

1997

1997

Publication Date:
20 April 2007 (online)

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Abstract

To study the effect of a therapeutic dose (3µM) of AY-4166 on the glucose-stimulated insulin secretion, the rat pancreas was perfused with 5∼15 mM glucose. AY-4166 did not affect the basal insulin secretion at 5 mM glucose, and increased the first and second phases of insulin secretion stimulated by 7.5∼15 mM glucose. The dose-response curve of the insulin secretion to glucose was shifted to the left side by AY-4166. These results suggest that AY-4166 ist not a stimulator releasing insulin independently of glucose concentrations, but a potentiator of insulin secretion.

Key words

AY-4166 - Insulin - Glucose dependency - Potentiator - Pancreas perfusion

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