Apoptosis in Brain Biopsies of Subacute Sclerosing Panencephalitis Patients

B. Anlar; F. Söylemezoǧlu; B. Elibol; T. Dalkara; S. Aysun; G. Köse; D. Belen; K. Yalaz

doi:10.1055/s-2007-973497

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Neuropediatrics 1999; 30(5): 239-242
DOI: 10.1055/s-2007-973497

Original articles

Apoptosis in Brain Biopsies of Subacute Sclerosing Panencephalitis Patients

B. Anlar¹ , F. Söylemezoǧlu² , B. Elibol⁵ , T. Dalkara⁵ , S. Aysun¹ , G. Köse³ , D. Belen⁴ , K. Yalaz¹

¹Department of Pediatric Neurology, Hacettepe University, Ankara, Turkey
²Department of Pathology, Hacettepe University, Ankara, Turkey
³Department of Pediatric Neurology, SSK Ankara Hospital, Ankara, Turkey
⁴Department of Neurosurgery, SSK Ankara Hospital, Ankara, Turkey
⁵Department of Neurology, Hacettepe University, Ankara, Turkey

Further Information

Publication History

Publication Date:
12 March 2007 (online)

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Abstract

Subacute sclerosing panencephalitis (SSPE) is associated with inflammatory infiltration, neuronal loss, and demyelination. The pathogenesis of these changes is unclear. We examined DNA fragmentation and Bcl-2 expression in brain biopsies of nineteen SSPE patients to investigate the role of apoptosis in tissue damage. DNA fragmentation was present in oligoden-droglia, and, in tissues with neuronal loss, in neurons. Reactive astrocytes had no DNA fragmentation, but strong Bcl-2 expression. These results suggest apoptosis as one of the mechanisms for oligodendroglial and neuronal death in SSPE.

Key words

Apoptosis - Subacute sclerosing panencephalitis - Measles

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