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Planta Med 1994; 60(2): 114-117
DOI: 10.1055/s-2006-959429
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© Georg Thieme Verlag Stuttgart · New York

Effects of Nardostachys jatamansi on Biogenic Amines and Inhibitory Amino Acids in the Rat Brain

Vidya Prabhu M.1 , K. Sudhakar Karanth2 , Anjali Rao1
  • 1Department of Biochemistry, Kasturba Medical College, Manipal-576 119, Karnataka, India
  • 2Department of Pharmacology, Kasturba Medical College, Manipal-576 119, Karnataka, India
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Publication History

1993

1993

Publication Date:
04 January 2007 (online)

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Abstract

The effect of acute and subchronic administration of an alcoholic extract of the roots of Nardostachys jatamansi on norepinephrine (NE), dopamine (DA), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), γ-aminobutyric acid (GABA), and taurine were studied in male albino Wistar rats. The acute oral administration of the extract did not change the level of NE and DA but resulted in a significant increase in the level of 5-HT and 5-HIAA. A significant increase in the level of GABA and taurine was observed in the drug-treated groups when compared to the controls. A 15-day treatment resulted in a significant increase in the levels of NE, DA, 5-HT, 5-HIAA, and GABA. These data indicate that the alcoholic extract of the roots of N. jatamansi causes an overall increase in the levels of central monoamines and inhibitory amino acids.

Key words

Nardostachys jatamansi - Valerianaceae - biogenic amines - GABA - taurine - brain

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