Cytotoxic Coumarins from the Aerial Parts of Tordylium apulum and their Effects on a Non-Small-Cell Bronchial Carcinoma Cell Line

Constantinos Kofinas; loanna Chinou; Anargiros Loukis; Catherine Harvala; Christos Roussakis; Marc Maillard; Kurt Hostettmann

doi:10.1055/s-2006-957398

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Planta Med 1998; 64(2): 174-176
DOI: 10.1055/s-2006-957398

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© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Coumarins from the Aerial Parts of Tordylium apulum and their Effects on a Non-Small-Cell Bronchial Carcinoma Cell Line

Constantinos Kofinas¹ , loanna Chinou¹ , Anargiros Loukis¹ , Catherine Harvala¹ , Christos Roussakis² , Marc Maillard³ , Kurt Hostettmann³

¹Division of Pharmacognosy, University of Athens, Athens, Greece
²ISOMER Laboratoire de Pharmacognosie Marine, Universite de Nantes, Faculte de Pharmacie, Nantes, France
³Institute de Pharmacognosie et Phytochimie, Universite de Lausanne, Lausanne, Switzerland

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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Seven coumarins were isolated from the aerial parts of Tordylium apulum; their structures were established by spectroscopic means. All compounds were tested in vitro for their cytotoxicity against two cell line systems. The antiproliferative effects for three of them were studied at the level of the cell cycle in asynchronous cells of the NSCLC-N6 line with a flow cytometry apparatus.

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