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Planta Med 2003; 69(9): 859-861
DOI: 10.1055/s-2003-43207
Letter
© Georg Thieme Verlag Stuttgart · New York

A new Anti-HIV Flavonoid Glucuronide from Chrysanthemum morifolium

Ji Sun Lee1 , Hyoung Ja Kim1 , Yong Sup Lee1
  • 1Division of Life Sciences, Korea Institute of Science and Technology, Cheongryang, Seoul, Korea
Further Information

Publication History

Received: February 10, 2003

Accepted: May 31, 2003

Publication Date:
04 November 2003 (online)

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Abstract

A new flavonoid glucuronide, apigenin 7-O-β-D-(4′-caffeoyl)glucuronide (1), and the known compound, apigenin 7-O-β-D-glucurnoide, were isolated from the flowers of Chrysanthemum morifolium, along with five known flavonoids. The structure of 1 was elucidated by the aid of spectroscopic analyses. Among isolated compounds, apigenin 7-O-β-D-(4″-caffeoyl)glucuronide showed strong HIV-1 integrase inhibitory activity (IC50 = 7.2 ± 3.4 μg/ml) and anti-HIV activity in a cell culture assay (EC50 = 41.86 ± 1.43 μg/ml) using HIV-IIIIB infected MT-4 cells.

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Yong Sup Lee, Ph.D.

Medicinal Chemistry Research Center

Korea Institute of Science and Technology

P.O. Box 131

Cheongryang

Seoul 130-650

Korea

Phone: +82-2-958-5167

Fax: +82-2-958-5189

Email: yslee@kist.re.kr

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