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Int J Sports Med 2009; 30(12): 888-891
DOI: 10.1055/s-0029-1238291
Genetics & Molecular Biology

© Georg Thieme Verlag KG Stuttgart · New York

Is There an ACE ID – ACTN3 R577X Polymorphisms Interaction that Influences Sprint Performance?

N. Eynon1 , A. J. Alves2 , C. Yamin1 , M. Sagiv1 , J. A. Duarte3 , J. Oliveira2 , M. Ayalon4 , E. Goldhammer5 , M. Sagiv1 , Y. Meckel1
  • 1Zinman College of Physical Education and Sports Sciences at the Wingate Institute, Genetics and Molecular Biology, Netanya, Israel
  • 2Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal
  • 3Sport Biology, University of Porto, Porto, Portugal
  • 4Zinman College of Physical Education, Biomechanics, Wingate Institute, Netanya, Israel
  • 5Bnai-Zion Haifa Medical Center, Heart Institute, Haifa, United States
Further Information

Publication History

accepted after revision July 30, 2009

Publication Date:
10 December 2009 (online)

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Abstract

Functional R577X (rs.1815739) and ID (rs.5186) polymorphisms in the α-actinin-3 (ACTN3) and the angiotensin converting enzyme (ACE) genes, respectively, have been associated with sprint performance. The aim of this study was to determine their effect on sprint performance among 81 Israeli sprinters and 240 healthy controls. Results revealed that the ACE II genotype+ACTN3 R allele (P=0.003 for sprinters vs. controls), and the ACTN3 RR genotype+ACE I allele (P=0.001 for sprinters vs. controls) might be the genotype for sprinters. In the whole cohort the probability of ACTN3 RR genotype+ ACE I allele being a sprinter (odds ratio 2.67, 95% confidence interval 1.45–4.93) and of ACE II genotype+ACTN3 R allele being a sprinter (odds ratio 3.57, 95% confidence interval 1.78–7.15) was significantly higher than that in the controls. In conclusion, the above data suggest that ACE ID/ACTN3 R577X genotype combination is associated with sprint ability. However, ACE ID/ACTN3 R577X genotype combination is not related to the level of performance.

Key words

genotype frequencies - genetics - top-level athletes

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Correspondence

Dr. N. Eynon

The Zinman College of Physical Education and Sports Sciences at the Wingate Institute,

Genetics and Molecular Biology

Netanya

Israel

Phone: 09/863 96 38

Fax: 09/863 96 35

Email: eynon@wincol.ac.il

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