Involvement of Sex Hormone in Body Weight Gain by Selective D2 Receptor Antagonist Sulpiride

H. Shimizu; Y. Shimomura; Y. Uehara; I. Kobayashi; S. Kobayashi

doi:10.1055/s-0029-1210984

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Exp Clin Endocrinol Diabetes 1990; 96(4): 25-29
DOI: 10.1055/s-0029-1210984

Original

Involvement of Sex Hormone in Body Weight Gain by Selective D₂ Receptor Antagonist Sulpiride

H. Shimizu, Y. Shimomura, Y. Uehara, I. Kobayashi, S. Kobayashi

First Department of Internal Medicine, Section of Endocrinology, Central Laboratory for Clinical Investigation, Gunma University School of Medicine, Maebashi/Japan

Further Information

Publication History

1989

Publication Date:
16 July 2009 (online)

Also available at

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Summary

The effect of estrogen supplement on selective D₂ receptor antagonist sulpiride induced weight gain was examined in ovariectomized (ovx.) rats. Sulpiride injection (10 mg/kg, s.c.) showed a significant increase of body weight and food consumption only in female rats. Bilateral ovariectomy completely abolished the weight gain and hyperphagia by sulpiride. Subcutaneous injection of estradiol benzoate (E₂ : 5 μg/day, s. c.) for 14 days restored the effects of sulpiride on weight gain in ovx. rats and sulpiride injection with E₂ supplement significantly increased the efficiency of food utilization. The present study suggested that estrogen should be involved in the induction of overweight and hyperphagia by sulpiride.

Key words

Sulpiride - Estrogen - Feeding behavior - Rat

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