Download PDF
Exp Clin Endocrinol Diabetes 1985; 85(2): 249-252
DOI: 10.1055/s-0029-1210445
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Effect of Beta-Casomorphin and Its Analogue on Serum Prolactin in the Rat

J. Nedvídková, E. Kasafírek, A. Dlabač, V. Felt
  • Research Institute of Endocrinology, (Deputy director: MUDr. RNDr. L. Stárka, DrSc) and Research Institute for Pharmacy and Biochemistry (Director: MUDr. A. Dlabač, DrSc), Praha/Czechoslovakia
Further Information

Publication History

1984

Publication Date:
16 July 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

The effects of exogenous opioid peptides beta-casomorphin Tyr-Pro-Phe-Pro-Gly-Pro-Ile and its analogue Tyr-Pro-Gly-Pro-Phe-Pro-Ile (analogue I) were found to increase proiactin level in plasma after intraperitoneal injection. Analogue I was more potent. This effect of beta-casomorphin and analogue I were blocked by an opioid antagonist, naloxone.

These results indicate that the exogenous opioid peptides (exorphins) may participate in the regulation of proiactin secretion. The similarity of analogue I with enkephalin structure was discussed.

Key words

Beta-casomorphin - prolactin - naloxone

      >