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Skull Base 2009; 19(3): 219-224
DOI: 10.1055/s-0028-1114295
ORIGINAL ARTICLE

© Thieme Medical Publishers

Carbon Ion Radiotherapy for Skull Base Chordoma

Jun–etsu Mizoe1 , Azusa Hasegawa1 , Ryo Takagi1 , Hiroki Bessho1 , Takeshi Onda1 , Hirohiko Tsujii1
  • 1Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences (NIRS), Chiba, Japan
Further Information

Publication History

Publication Date:
09 January 2009 (online)

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ABSTRACT

Objective: To present the results of the clinical study of carbon ion radiotherapy (CIRT) for skull base and paracervical spine tumors at the National Institute of Radiological Sciences in Chiba, Japan. Methods: The study is comprised of three protocols: a pilot study, a phase I/II dose escalation study, and a phase II study. All the patients were treated by 16 fractions for 4 weeks with total doses of 48.0, 52.8, 57.6, and 60.8 Gy equivalents (GyE). Results: As a result of the dose escalation study of CIRT for skull base tumors, a dose fractionation of 60.8 GyE/16 fractions for 4 weeks was decided as the recommended dose because of acceptable normal tissue reactions and good local tumor control. Conclusions: Preliminary results of the phase II clinical study of CIRT for skull base chordoma showed local control at 5 years at 100%, and normal tissues showed a mild reaction without any severe morbidity of important organs.

KEYWORDS

Chordoma - carbon ion radiotherapy - particle radiotherapy - skull base tumor

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Jun–etsu MizoeM.D. Ph.D. 

Research Center for Charged Particle Therapy Hospital, National Institute of Radiological Sciences (NIRS)

Anagawa 4-9-1, Inage-ku, 263-8555, Chiba, Japan

Email: j_mizoe@nirs.go.jp

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