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Concurrent Impairments in Sleep and Memory in Amnestic Mild Cognitive Impairment

Published online by Cambridge University Press:  03 February 2012

Carmen E. Westerberg ,
Bryce A. Mander ,
Susan M. Florczak ,
Sandra Weintraub ,
M.-Marsel Mesulam ,
Phyllis C. Zee  and
Ken A. Paller
Carmen E. Westerberg*
Affiliation:
Psychology Department and Interdepartmental Neuroscience Program, Northwestern University, Evanston, Illinois Psychology Department, Texas State University, San Marcos, Texas
Bryce A. Mander
Affiliation:
Psychology Department, University of California, Berkeley, California
Susan M. Florczak
Affiliation:
Psychology Department and Interdepartmental Neuroscience Program, Northwestern University, Evanston, Illinois
Sandra Weintraub
Affiliation:
Psychology Department and Interdepartmental Neuroscience Program, Northwestern University, Evanston, Illinois Cognitive Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Chicago, Illinois Neurology Department, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
M.-Marsel Mesulam
Affiliation:
Cognitive Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois Neurology Department, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
Phyllis C. Zee
Affiliation:
Neurology Department, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
Ken A. Paller
Affiliation:
Psychology Department and Interdepartmental Neuroscience Program, Northwestern University, Evanston, Illinois
*
Correspondence and reprint requests to: Carmen E. Westerberg, Department of Psychology, Texas State University, San Marcos, 601 University Drive, San Marcos, TX 78666. E-mail: cw54@txstate.edu
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Abstract

Whereas patients with Alzheimer's disease (AD) experience difficulties forming and retrieving memories, their memory impairments may also partially reflect an unrecognized dysfunction in sleep-dependent consolidation that normally stabilizes declarative memory storage across cortical areas. Patients with amnestic mild cognitive impairment (aMCI) exhibit circumscribed declarative memory deficits, and many eventually progress to an AD diagnosis. Whether sleep is disrupted in aMCI and whether sleep disruptions contribute to memory impairment is unknown. We measured sleep physiology and memory for two nights and found that aMCI patients had fewer stage-2 spindles than age-matched healthy adults. Furthermore, aMCI patients spent less time in slow-wave sleep and showed lower delta and theta power during sleep compared to controls. Slow-wave and theta activity during sleep appear to reflect important aspects of memory processing, as evening-to-morning change in declarative memory correlated with delta and theta power during intervening sleep in both groups. These results suggest that sleep changes in aMCI patients contribute to memory impairments by interfering with sleep-dependent memory consolidation. (JINS, 2012, 18, 490–500)

Keywords

Long-term memoryMemory consolidationMild cognitive impairmentSlow-wave sleepPolysomnographyAging
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 18 , Issue 3 , May 2012 , pp. 490 - 500
Copyright
Copyright © The International Neuropsychological Society 2012

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