Hostname: page-component-848d4c4894-5nwft Total loading time: 0 Render date: 2024-05-22T10:28:30.865Z Has data issue: false hasContentIssue false

Nutritional factors in stroke

Published online by Cambridge University Press:  09 March 2007

S. E. Gariballa*
Affiliation:
Sheffield Institute for Studies on Ageing, The University of Sheffield, Barnsley District General Hospital, Gawber Road, Barnsley S75 2EP, UK
*
Corresponding author: Dr S. E. Gariballa, fax +44 (0) 1226 777705, email S.E.Gariballa@sheffield.ac.uk
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Observational studies support the role of modifying lifestyle-related risk factors such as diet, physical activity and alcohol use in stroke prevention. For example, increased Na intake is associated with hypertension, and reduction in salt consumption may significantly lower blood pressure and may reduce stroke mortality. Moderately elevated homocysteine levels may be associated with stroke and are associated with deficiency of dietary intake of folate, vitamin B6 and vitamin B12. Consumption of a diet rich in fruits, vegetables, folate, K, Ca, Mg, dietary fibre, fish and milk may protect against stroke. Regular physical activity may also protect against stroke through its role in controlling various risk factors such as hypertension, diabetes mellitus and obesity. The role of fat intake as a risk factor for stroke remains uncertain, whereas the association between stroke and cholesterol has more convincingly been demonstrated by the recent intervention trials using statins. There is also evidence that a low serum albumin may be causally linked to stroke risk and outcome and that a significant number of stroke patients are undernourished on admission and their nutritional status deteriorates further whilst in hospital. Undernutrition is associated with increasing morbidity and mortality and nutritional supplements may have some beneficial effect on some outcome measures.

Type
Review article
Copyright
Copyright © The Nutrition Society 2000

References

Abbott, RD, Behrens, GR, Sharp, DS, Rodriguez, BL, Burchfiel, CM, Ross, GM, Yano, K and Curb, JD (1994) Body mass index and thromboembolic stroke. Stroke 25, 23702376.CrossRefGoogle ScholarPubMed
Abbott, RD, Curb, JD, Rodriguez, BL, Sharp, DS, Burchfiel, CM and Yano, K (1996) Effect of dietary calcium and milk consumption on risk of thromboembolic stroke in older middle-aged men. Stroke 27, 813818.CrossRefGoogle ScholarPubMed
Acheson, RM and Williams, DRR (1983) Does consumption of fruit and vegetables protect against stroke. Lancet i, 11911193.CrossRefGoogle Scholar
Ascherio, A, Rimm, EB, Hernan, MA, Giovannucci, EL, Kawachi, I, Stampfer, MJ and Willett, WC (1998) Intake of potassium, magnesium, calcium and fiber and risk of stroke among US men. Circulation 98, 11981204.CrossRefGoogle ScholarPubMed
Axelsson, K, Asplund, K, Norberg, A and Alafuzoff, L (1988) Nutritional status in patients with acute stroke. Acta Medica Scandinavica 224, 217224.CrossRefGoogle ScholarPubMed
Axelsson, K, Asplund, K, Norberg, A and Eriksson, S (1989) Eating problems of patients with severe stroke. Journal of the American Dietetic Association 89, 10921096.CrossRefGoogle ScholarPubMed
Axelsson, K, Norberg, A and Asplund, K (1984) Eating after stroke. International Nursing Studies 21, 9399.CrossRefGoogle Scholar
Barer, D, Leibowitz, R, Ebrahim, S, Pengally, D and Neale, R (1989) Vitamin C status in patients with stroke and other acute illnesses. Journal of Clinical Epidemiology 42, 625631.CrossRefGoogle ScholarPubMed
Barker, DJ (1997) Foetal nutrition and cardiovascular disease in later life. British Medical Bulletin 53, 96108.CrossRefGoogle ScholarPubMed
Barker, DJP, Osmond, C and Pannett, B (1992) Why Londoners have low death rates from ischaemic heart disease and stroke. British Medical Journal 305, 15511554.CrossRefGoogle ScholarPubMed
Beamer, N, Coull, BM, Sexton, G, de Garmo, P, Knox, R and Seaman, G (1993) Fibrinogen and the albumin-globulin ratio in recurrent stroke. Stroke 24, 11331139.CrossRefGoogle ScholarPubMed
Bertron, P, Barnard, ND and Mills, M (1999) Racial bias in federal nutrition policy, Part II: Weak guidelines take a disproportionate toll. Journal of the National Medical Association 91, 201208.Google Scholar
Blair, SN, Kampert, JB, Kohl, HW, Barlow, CE, Macera, CA, Pallenbarger, RS and Gibbons, LW (1996) Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. Journal of the American Medical Association 276, 205210.CrossRefGoogle ScholarPubMed
Biller, J, Feinberg, WM, Castaldo, JE, Whittemore, AD, Harbaugh, RE, Dempsey, RJ, Caplan, LR, Kresowik, TF, Matchar, DB and Toole, JF (1998) Guidelines for carotid endarterectomy: a statement for healthcare professionals, American Heart Association. Circulation 97, 501509.CrossRefGoogle ScholarPubMed
Burr, ML and Philips, KM (1984) Anthropometric norms in the elderly. British Journal of Nutrition 51, 165169.CrossRefGoogle ScholarPubMed
Choi-Kwon, S, Yang, YH, Kim, EK, Jeon, MY and Kim, JS (1998) Nutrition status in acute stroke: undernutrition versus overnutrition on different stroke subtypes. Acta Neurologica Scandinavica 98, 187192.CrossRefGoogle ScholarPubMed
Crouse, PR, Byington, RP, Hoen, HM and Furberg, CD (1997) Reductase inhibitor monotherapy and stroke prevention. Archives of Internal Medicine 157, 13051310.CrossRefGoogle ScholarPubMed
Davalos, A, Ricart, W, Gonzalez-Huix, F, Soler, S, Marrugat, J, Molins, A, Sumer, R and Genis, D (1996) Effect of malnutrition after acute stroke on clinical outcome. Stroke 27, 10281032.CrossRefGoogle ScholarPubMed
De Keyser, J, De Klippel, N, Merkx, H, Vervaeck, M and Herroelen, L (1992) Serum concentrations of vitamin A and E and early outcome after ischaemic stroke. Lancet 339, 15621565.CrossRefGoogle Scholar
Department of Health and Social Security (1992) Nutrition in the Elderly. Report on Health and Social Subjects no. 43. London: H.M. Stationery Office.Google Scholar
Donahue, RP, Abbott, RD, Reed, DM and Yano, K (1986) Alcohol and hemorrhagic stroke: The Honolulu Heart Program. Journal of American Medical Association 255, 2311.CrossRefGoogle ScholarPubMed
Evans, E and Fotherby, MD (1999) Cholesterol and stroke. Reviews in Clinical Gerontology 9, 112.CrossRefGoogle Scholar
Evans, E and Stock, AL (1971) Dietary intake of geriatric patients in hospital. Nutrition and Metabolism 13, 2135.CrossRefGoogle Scholar
Folsom, AR, Rasmussen, ML, Chambless, LE, Howard, G, Cooper, LS, Schmidt, MI and Heiss, G (1999) Prospective associations, of fasting insulin, body fat distribution, and diabetes with risk of ischaemic stroke. Diabetes Care 22, 10771083.CrossRefGoogle Scholar
Fotherby, MD and Potter, JF (1993) Potassium supplementation reduces clinic and ambulatory blood pressure in elderly hypertensive patients. Journal of Hypertension 10, 14031408.CrossRefGoogle Scholar
Gale, CR, Martyn, CN, Winter, PD and Cooper, C (1995) Vitamin C and risk of death from stroke and coronary heart disease in a cohort of elderly people. British Medical Journal 310, 15631566.CrossRefGoogle Scholar
Gariballa, SE, Robinson, TG and Fotherby, MD (1997) Hypokalaemia and potassium excretion in stroke patients. Journal of the American Geriatric Society 45, 14541458.CrossRefGoogle ScholarPubMed
Gariballa, SE and Sinclair, AJ (1998) Assessment and treatment of nutritional status in stroke patients. Postgraduate Medical Journal 74, 395399.CrossRefGoogle ScholarPubMed
Gariballa, SE, Taub, N, Parker, SG and Castleden, CM (1998) Nutritional status of hospitalized acute stroke patients. British Journal of Nutrition 79, 481487.CrossRefGoogle ScholarPubMed
Gariballa, SE, Taub, N, Parker, SG and Castleden, CM (1998) The influence of nutritional status on clinical outcome after acute stroke. American Journal of Clinical Nutrition 68, 275281.CrossRefGoogle ScholarPubMed
Gariballa, SE, Taub, N, Parker, SG and Castleden, CM (1998) A randomised control trial of oral nutritional supplements following acute stroke. Journal of Parenteral and Enteral Nutrition 22, 315319.CrossRefGoogle ScholarPubMed
Gey, KF, Moser, UK, Jordan, P, Stahelin, HB, Eichholzer, M and Ludin, E (1993) Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants. American Journal of Clinical Nutrition 57 (Suppl.), 787S797S.CrossRefGoogle ScholarPubMed
Gey, KF, Stahelin, HB and Eichholzer, M (1993) Poor plasma status of carotene and vitamin C is associated with higher mortality from ischaemic heart disease and stroke. Clinical Investigation 71, 36.Google ScholarPubMed
Giles, WH, Croft, JB, Greenlund, KJ, Ford, ES and Kittner, SJ (1998) Total homocysteine concentration and the likelihood of nonfatal stroke: results from the Third National Health and Nutritional Survey, 1988–1994. Stroke 29, 24732474.CrossRefGoogle ScholarPubMed
Giles, WH, Kittner, SJ, Anda, RF, Croft, JB and Casper, ML (1995) Serum folate and risk for ischaemic stroke. Stroke 26, 11661170.CrossRefGoogle Scholar
Gill, JS, Zezulka, AV, Shipley, MJ, Gill, SK and Beevers, DG (1986) Stroke and alcohol consumption. New England Journal of Medicine 315, 10411046.CrossRefGoogle ScholarPubMed
Gillman, MW, Cupples, LA, Gagnon, D, Posner, BM, Ellison, RC, Castelli, WP and Wolf, PA (1995) Protective effect of fruits and vegetables on development of stroke in men. Journal of the American Medical Association 273, 11131117.CrossRefGoogle ScholarPubMed
Gillman, MW, Cupples, LA, Millen, BE, Ellison, RC and Wolfe, PA (1997) Inverse association of dietary fat with development of ischaemic stroke in men. Journal of the American Medical Association 278, 21452150.CrossRefGoogle ScholarPubMed
Gillum, RF, Ingram, DD and Makuc, DM (1994) Relation between serum albumin concentration and stroke incidence and death: The NHANES 1 Epidemiologic Follow-up Study. American Journal of Epidemiology 140, 876888.CrossRefGoogle Scholar
Gillum, RF and Makuc, DM (1992) Serum albumin, coronary heart disease and death. American Heart Journal 123, 507513.CrossRefGoogle ScholarPubMed
Gillum, RF, Mussolino, ME and Madans, JH (1996) The NHANES 1 Epidemiologic Follow-up Study. Archives of Internal Medicine 156, 537542.CrossRefGoogle Scholar
Gorelick, PB (1989) The status of alcohol as a risk factor for stroke. Stroke 20, 16071610.CrossRefGoogle ScholarPubMed
Gorelick, PB, Sacco, RL, Smith, DB, Alberts, M, Mustone-Alexander, L, Rader, D, Ross, JL and Raps, E (1999) Prevention of a first stroke: a review of guidelines and multidisciplinary consensus statement from the National Stroke Association. Journal of the American Medical Association 281, 11121120.CrossRefGoogle ScholarPubMed
Hennekens, CH, Buring, JE, Manson, JE, Stamper, M, Posner, B, Cook, NR, Belanger, C, LaMotte, F, Gaziano, JM, Ridker, PM, Willett, W and Peto, R (1996) Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasm and cardiovascular disease. New England Journal of Medicine 334, 11451149.CrossRefGoogle ScholarPubMed
Herbert, PR, Gaziano, JM, Chan, KS and Hennekens, CH (1997) Cholesterol lowering with statin drugs, risk of stroke, and total mortality. Journal of the American Medical Association 278, 313321.Google Scholar
Herbert, PR, Gaziano, JM and Hennekens, CH (1985) An overview of trials of cholesterol lowering and risk of stroke. Archives of Internal Medicine 155, 5055.CrossRefGoogle Scholar
Houston, PE, Rana, S, Sekhsaria, S, Perlin, E, Kim, KS and Castro, OL (1997) Homocysteine in sickle cell disease: relationship to stroke. American Journal of Medicine 103, 192196.CrossRefGoogle ScholarPubMed
Intersalt Cooperative Research Group (1988), –. Intersalt (1988) an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. British Medical Journal 297, 319328.CrossRefGoogle Scholar
Kagan, A, Popper, JS, Rhoads, GG and Yano, K (1985) Dietary and other risk factors for stroke in Hawaiian Japanese men. Stroke 16, 390396.CrossRefGoogle ScholarPubMed
Kang, SS, Wong, PWK and Norusis, M (1987) Homocysteinemia due to folate deficiency. Metabolism 36, 458462.CrossRefGoogle ScholarPubMed
Keli, SO, Hertog, MGL, Feskens, EJM and Kromhout, D (1996) Dietary flavonoids, antioxidant vitamins, and incidence of stroke. Archives of Internal Medicine 154, 637642.CrossRefGoogle Scholar
Khaw, KT and Barrett-Connor, E (1987) Dietary potassium and stroke associated mortality. A 12-year prospective population study. New England Journal of Medicine 316, 235239.CrossRefGoogle ScholarPubMed
Kimura, N, Toshima, H, Nakayama, Y, Mizuguchi, T and Fukami, T (1972) Population survey on cerebrovascular and cardiovascular diseases. The ten years experience in the farming village of Tanushimaru and the fishing village of Ushibuka. Japanese Heart Journal 13, 118127.CrossRefGoogle ScholarPubMed
Kokkinos, PF, Narayan, P, Colleran, JA, Pitteras, A, Notargiacoma, A, Reda, D and Papademertriou, V (1995) Effects of regular exercise on blood pressure and left ventricular hypertrophy in African-American men with severe hypertension. New England Journal of Medicine 333, 14621467.CrossRefGoogle ScholarPubMed
Kuller, LH, Eichner, JE, Orchard, TJ, Grandits, GA, McCallum L and Tracey, R (1991) The relation between serum albumin levels and risk of coronary heart disease in the Multiple Risk factor Intervention Trial. American Journal of Epidemiology 134, 12661277.CrossRefGoogle ScholarPubMed
Lakka, TA and Salonen, JT (1993) Moderate to high intensity conditioning leisure time physical activity and high cardiorespiratory fitness are associated with reduced plasma fibrinogen in eastern Finnish men. Journal of Clinical Epidemiology 46, 11191127.CrossRefGoogle ScholarPubMed
Langford, HG (1983) Dietary potassium and hypertension: epidemiologic data. Annals of Internal Medicine 9, 770772.CrossRefGoogle Scholar
Lennard-Jones, JE (1999) Giving or withholding fluids and nutrients: ethical and legal aspects. Journal of the Royal College of Physicians of London 33, 3945.Google ScholarPubMed
Lindenstrom, E, Boysen, G and Nyboe, J (1994) Influence of total cholesterol, HDL and triglyceride on risk of cerebrovascular disease. British Medical Journal 309, 1115.CrossRefGoogle ScholarPubMed
Lindgren, A, Brattstrom, L, Novrrving, B, Hultberg, B, Andersson, A and Johansson, BB (1995) Plasma homocysteine in the acute and convalescent phases after stroke. Stroke 26, 795800.CrossRefGoogle ScholarPubMed
McGee, D, Reed, D, Stemmerman, G, Rhoads, G, Yano, K and Feinleib, M (1985) The relationship of dietary fat and cholesterol to mortality in 10 years. International Journal of Epidemiology 14, 97105.CrossRefGoogle Scholar
MacGregor, GA (1983) Sodium and potassium intake and the blood pressure. Hypertension 5, 7984.CrossRefGoogle Scholar
Mahony, EH (1973) Nutritional care of the stroke patient. Archives of Physical and Medical Rehabilitation 54, 569570.Google Scholar
Malinow, MR, Bostom, AG and Krauss, RM (1999) Homocysteine, diet, and cardiovascular disease: for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 99, 178182.CrossRefGoogle ScholarPubMed
Manson, JE, Rimm, EB, Stampfer, MJ, Colditz, GA, Willet, WC, Krolewski, AS, Rosner, B, Hennekens, CH and Speizer, FE (1991) Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 338, 774778.CrossRefGoogle ScholarPubMed
Manson, JE, Stampfer, MJ, Willett, WC, Colditz, GA, Speizer, FE and Hennekens, CH (1993) Antioxidant vitamin consumption and incidence of stroke in women. Circulation 87,.Google Scholar
Martin, JMeltzer, H & Elliot, D (1988) OPCS Survey of Disability in Great Britain. Report I: The Prevalence of Disability Among Adults. Office of Population Census and Survey. London: H.M. Stationery Office.Google Scholar
Molloy, AM, Daly, S, Mills, JL, Kirke, PN, Whitehead, AS, Ramsbottom, D, Conley, MR, Weir, DG and Scot, JM (1997) Thermolabile variant of 5, 10 methylenetetrahydrofolate reductase associated with low red-cell folates: implication for folate intake recommendations. Lancet 349, 15911593.CrossRefGoogle Scholar
Neaton, JD, Blackburn, H, Jacobs, G, Kuller, L, Lee, DJ, Sherwin, R, Shih, J, Stamler, J and Wentworth, D (1992) Serum cholesterol level and mortality findings. Archives of Internal Medicine 152, 14901500.CrossRefGoogle ScholarPubMed
Norton, B, Homer-Ward, M, Donnelly, DM, Long, RG and Holmes, GK (1996) A randomised prospective comparison of percutaneous endoscopic gastrotomy and nasogastric tube feeding after acute dysphasic stroke. British Medical Journal 312, 1316.CrossRefGoogle Scholar
Nyswonger, GD and Helmchen, RH (1992) Early enteral nutrition and length of stay in stroke patients. Journal of Neuroscience Nursing 24, 220223.CrossRefGoogle ScholarPubMed
Orencia, AJ, Daviglus, ML, Dyer, AR, Shekelle, RB and Stamler, J (1996) Fish consumption and stroke in men. Stroke 27, 204209.CrossRefGoogle ScholarPubMed
Pellegrini, N, Pareti, FI, Stabile, F, Brusamolino, A and Simonetti, P (1996) Effects of moderate consumption of red wine on platelet aggregation and haemostatic variables in healthy volunteers. European Journal of Clinical Nutrition 50, 209213.Google ScholarPubMed
Perry, IJ, Refsum, H, Morris, RW, Ebrahim, SB, Ueland, PM and Shaper, AG (1995) Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 346, 13951398.CrossRefGoogle ScholarPubMed
Petri, M, Roubenoff, R, Dallal, GE, Nadeau, MR, Selhub, J and Rosenberg, IH (1996) Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosus. Lancet 348, 11201124.CrossRefGoogle ScholarPubMed
Phillips, A, Shaper, AG and Whincup, PH (1989) Association between serum albumin and mortality from cardiovascular disease, cancer and other causes. Lancet ii, 14341436.CrossRefGoogle Scholar
Poungvarin, N (1998) Stroke in the developing world. Lancet 352(sIII), 1921.CrossRefGoogle ScholarPubMed
Qureshi, AI, Giles, WH and Croft, JB (1999) Racial differences in the incidence of intracerebral haemorrhage: effect of blood pressure and education. Neurology 52, 16171621.CrossRefGoogle ScholarPubMed
Rangemark, C, Hedner, JA, Carlson, JT, Gleerup, G and Winther, K (1995) Platelet function and fibrinolytic activity in hypertensive and normotensive sleep apnea patients. Sleep 18, 188194.CrossRefGoogle ScholarPubMed
Rabeneck, L, McCullough LB and Wray, NP (1997) Ethically justified, clinically comprehensive guidelines for percutaneous endoscopic gastrostomy tube placement. Lancet 349, 496498.CrossRefGoogle ScholarPubMed
Riemersma, RA, Wood, DA, Macintyre, CCA, Elton, RE, Gey, KF and Oliver, MF (1991) Risk of angina pectoris and plasma concentrations of vitamin A, C, E and carotene. Lancet 337, 15.CrossRefGoogle Scholar
Robinson, K, Arheart, K, Refsum, H, Brattstrom, L, Boers, G, Ueland, P, Rubba, P, Palma-Reis, R, Meleady, R, Daly, L, Witteman, J and Graham, I (1998) Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease: European COMAC Group. Circulation 97, 437443.CrossRefGoogle ScholarPubMed
Selhub, J, Jacques, PF, Wilson, PW, Rush, D and Rosenberg, IH (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. Journal of the American Medical Association 270, 26932698.CrossRefGoogle Scholar
Sullivan, DH and Walls, RC (1994) Impact of nutritional status on morbidity in a population of geriatric rehabilitation patients. Journal of the American Geriatric Society 42, 471477.CrossRefGoogle Scholar
Sullivan, DH, Walls, RC and Bopp, MM (1995) Protein–energy undernutrition and the risk of mortality. Journal of the American Geriatric Society 43, 507512.CrossRefGoogle ScholarPubMed
Suter, PM (1999) The effects of potassium, magnesium, calcium and fiber on risk of stroke. Nutritional Reviews 57, 8488.Google ScholarPubMed
Syme, SI, Marmot, MG, Kagan, A, Kato, H and Rhoads, G (1975) Epidemiological studies of coronary heart disease and stroke. American Journal of Epidemiology 102, 477480.CrossRefGoogle ScholarPubMed
Tobian, L, Lange, J, Ulm, K, Wold, L and Iwai, J (1985) Potassium reduces cerebral haemorrhage and death rate in hypertensive rats, even when blood pressure is not lowered. Hypertension 1(Suppl.), 11101114.Google Scholar
Thorton, J, Symes, C and Heaton, K (1983) Moderate alcohol intake reduces bile cholesterol saturation and raises HDL cholesterol. Lancet 2, 819822.CrossRefGoogle Scholar
Unosson, M, Ek, AC, Bjurulf, P, von Schenck, H and Larsson, J (1994) Feeding dependence and nutritional status after acute stroke. Stroke 25, 366371.CrossRefGoogle ScholarPubMed
Vartiainen, E, Sarti, C, Tuomilehto, J and Kuulasmaa, K (1995) Do changes in cardiovascular risk factors explain changes in mortality from stroke in Finland?. British Medical Journal 310, 901904.CrossRefGoogle ScholarPubMed
Wade, DT (1992) Stroke: Rehabilitation. Lancet 339, 791793.CrossRefGoogle ScholarPubMed
Wade, DTHewer, RLSkilbeck, CE & David, R (1985) Stroke: A Critical Approach. London: Chapman and Hall.Google Scholar
Walker, SP, Rimm, EB, Ascherio, A, Kawachi, I, Stampfer, MJ and Willett, WC (1996) Body size and fat distribution as predictors of stroke among US men. American Journal of Epidemiology 144, 11431150.CrossRefGoogle ScholarPubMed
Williams, PT (1996) High-density lipoprotein cholesterol and other risk factors for coronary heart disease in female runners. New England Journal of Medicine 334, 12981303.CrossRefGoogle ScholarPubMed
Warlow, CPDennis, MS van Gijn, JHankey, GJSandercock, PAGBamford, JM & Wardlow, J (1996a) Reducing the burden of stroke and improving the public health. In Stroke: A Practical Guide to Management pp. 632649. [Warlow, CP, Dennis, MS, van Gijn, J, Hankey, GJ, Sandercock, PAG, Barlow, JM and Wardlow, J, editors]. Oxford: Blackwell Science Ltd.Google Scholar
Warlow, CPDennis, MS van Gijn, JHankey, GJSandercock, PAGBamford, JM & Wardlow, J (1996b) What pathological type of stroke is it? In Stroke: a Practical Guide to Management pp. 146189 [Warlow, CP, Dennis, MS, van Gijn, J, Hankey, GJ, Sandercock, PAG, Barlow, JM and Wardlow, J, editors]. Oxford: Blackwell Science Ltd.Google Scholar
Wang, JS, Jen, CJ and Chen, HI (1995) Effects of exercise training and deconditioning on platelet function in men. Arteriosclerosis Thrombosis Vascular Biology 15, 16681674.CrossRefGoogle ScholarPubMed
World Health Organization (1989) The WHO MONICA Project. World Health Stat Q 42, 27149.Google Scholar
Yamori, Y (1987) Hypertensive cerebrovascular disease: importance of nutrition in pathogenesis and prevention. Annals of the New York Academy of Science 92103.Google Scholar
Yamori, Y, Nara, Y, Mizushima, S, Sawamura, M and Horie, R (1994) Nutritional factors for stroke and major cerebrovascular disease. Health Reports (Statistics Canada) 6, 2227.Google Scholar
Young, B, Ott, L, Twyman, D, Norton, J, Rapp, R, Tibbs, P, Haack, P, Brivins, B and Dempsey, R (1987) The effect of nutritional support on outcome from severe head injury. Journal of Neurosurgery 67, 668676.CrossRefGoogle ScholarPubMed
Zhang, J, Sasaki, S, Amano, K and Kesteloot, H (1999) Fish consumption and mortality from all causes, ischaemic heart disease, and stroke: an epidemiological study. Preventive Medicine 28, 520529.CrossRefGoogle Scholar