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Interplay between polymorphisms and methylation in the H19/IGF2 gene region may contribute to obesity in Mexican-American children

Published online by Cambridge University Press:  20 September 2013

M. A. Hernández-Valero ,
J. Rother ,
I. Gorlov ,
M. Frazier  and
O. Gorlova
M. A. Hernández-Valero
Affiliation:
Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
J. Rother
Affiliation:
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
I. Gorlov
Affiliation:
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Lebanon, NH, USA
M. Frazier
Affiliation:
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
O. Gorlova*
Affiliation:
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Lebanon, NH, USA
*
*Address for correspondence: O. Gorlova, Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, One Medical Center Dr, Lebanon, NH 03756. (Email Olga.Y.Gorlova@dartmouth.edu)
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Abstract

Imprinted genes often affect body size-related traits such as weight. However, the association of imprinting with obesity, especially childhood obesity, has not been well studied. Mexican-American children have a high prevalence, approaching 50%, of obesity and/or overweight. In a pilot study of 75 Mexican-American children, we analyzed the relationships among obese/overweight status, methylation status and single-nucleotide polymorphism (SNP) status at a CpG site in a differentially methylated region (DMR) of the imprinted H19/IGF2 locus. We observed a significant difference in SNP rs10732516 frequency between boys and girls among the overweight and obese children but not among the lean children. We also found that children with lower methylation of the polymorphic CpG site (CpG4) in the H19 DMR had higher birth weights than did children with higher methylation (P = 0.04). Our results suggest that CpG4 methylation status may be associated with childhood obesity in Mexican-American children in a sex-specific manner.

Keywords

cellularchildrenepidemiologyepigeneticshumanmolecularnewbornpublic health
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 4 , Issue 6 , December 2013 , pp. 499 - 506
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2013 

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