Hostname: page-component-848d4c4894-2pzkn Total loading time: 0 Render date: 2024-05-27T04:09:25.439Z Has data issue: false hasContentIssue false
  • English
  • Français

Adenosine and Migraine

Published online by Cambridge University Press:  18 September 2015

R. Guieu ,
C. Devaux ,
H. Henry ,
G. Bechis ,
J. Pouget ,
D. Mallet ,
F. Sampieri ,
M. Juin ,
R. Gola  and
H. Rochat
R. Guieu*
Affiliation:
UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille
C. Devaux
Affiliation:
UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille
H. Henry
Affiliation:
Service de Neurologie CHU Bordeaux, Hopital Pellegrin, Bordeaux
G. Bechis
Affiliation:
UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille
J. Pouget
Affiliation:
Service des maladies Neuro-Musculaire, CHU Timone, Marseille
D. Mallet
Affiliation:
Laboratoire d'Hématologie, Hôpital Nord, Marseille
F. Sampieri
Affiliation:
UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille
M. Juin
Affiliation:
UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille
R. Gola
Affiliation:
Service de Stomatologie et Chirurgie Maxillo Faciale, Hôpital Nord, Marseille, France
H. Rochat
Affiliation:
UMR CNRS 6560, Faculté de Médecine Secteur Nord, Marseille
*
UMR CNRS 6560, Faculté de Médecine Secteur, Nord, Bd P Dramard 13020, Marseille, France.
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Background:

Adenosine is a powerful natural vasodilator that participates in the control of cerebral and meningeal blood flow. In this context, it could be involved in the pathophysiology of migraine, since it was previously reported that intravenous adenosine can precipitate crises in migraine patients.

Methods:

We have investigated circulating adenosine levels in 12 patients suffering from migraine without aura, during crises and in crisis-free periods, and have compared the levels noted to those of a population of 10 controls. To determine if there are interactions between adenosine and serotonin, we examined the effect of adenosine and antagonists on the uptake and the release of (14C) serotonin by platelets.

Results and conclusions:

We have reached a dual conclusion: 1) during migraine headaches there is an increase (mean 68%) in circulating adenosine levels and this increase may participate in cephalalgia; 2) activation of A2 receptors by adenosine causes a dose-dependent inhibition of calcium-dependent serotonin uptake by platelets. This inhibition of uptake could participate in the rapid elimination of serotonin in migraine sufferers. As a result of this, the use of adenosine antagonists could be an effective complementary treatment for migraine.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 25 , Issue 1 , February 1998 , pp. 55 - 58
Copyright
Copyright © Canadian Neurological Sciences Federation 1998

References

REFERENCES

1.Heistad, DD, Marcus, ML, Courley, JK. Effect of adenosine and dipyridamole on cerebral blood flow. Am J Physiol 1981; 240: 775–780.Google ScholarPubMed
2.Berne, RM, Winn, HR, Knabb, M, Ely, SW, Rubio, R. Blood flow regulation by adenosine in heart, brain and skeletal muscle. In: Berne, RM, Rail, TW, Rubio, R, Martinus, Nijhoff, eds. Regulatory Functions of Adenosine. Boston: 1983; 293–317.CrossRefGoogle Scholar
3.Collis, C, Brown, C. Adenosine relaxes the aorta by interacting with an A2 receptor and an intracellular site. Br J Pharmacol 1983; 79: 256p.Google Scholar
4.Edvinsson, L, Fredholm, BB. Characterization of adenosine receptors in isolated cerebral arteries of cat. Br J Pharmacol 1983; 80: 631–637.CrossRefGoogle ScholarPubMed
5.Haslam, RJ, Cusack, NJ. Blood platelets receptors for ADP and adenosine. In: Burnstock, G. Chapman, and Hall, , eds. Purinergic Receptors. London: 1981; 221–285.CrossRefGoogle Scholar
6.Sollevi, A. Cardiovascular effects of adenosine in man: possible clinical implication. Prog Neurobiol 1986; 27: 319–349.CrossRefGoogle Scholar
7.Pearson, JD, Slakeyand, LL, Gordon, JL. Stimulation of prostaglandin production through purinoreceptors on cultured porcine endothelial cells. Biochem J 1983; 214: 273–276.CrossRefGoogle ScholarPubMed
8.Brown, SGA, Waterer, GW. Migraine precipited by adenosine. Med J Austr l995; 162: 289–390.Google Scholar
9.Lundeberg, T. Vibratory stimulation for the alleviation of chronic pain. Acta Physiol Scand 1983; Suppl 523: 1–51.Google ScholarPubMed
10.Salter, MW, Henry, JL. Evidence that adenosine mediates the depression of spinal dorsal horn neurones induced by vibration in the cat. Neuroscience 1987; 22: 631–650.CrossRefGoogle ScholarPubMed
11.Bes, A, Kunkel, R, Lance, JW, et al. Classification and diagnostic criteria for headache disorders, cranial neuralgia and facial pain. Cephalalgia 1988; 8(Suppl 7): 1–96.Google Scholar
12.Guieu, R, Sampieri, F, Bechis, G, Rochat, H. Use of HPLC to measure circulating adenosine levels in migrainous patients. Clin Chim Acta 1994; 227: 185–194.CrossRefGoogle ScholarPubMed
13.Klabunde, RE, Althouse, DG. Adenosine metabolism in dog whole blood; effects of dipyridamole. Life Sci 1981; 23: 2631–2641.CrossRefGoogle Scholar
14.Haslam, RJ, Rosson, GM. Aggregation of human platelets by vasopressin. Am J Physiol 1972; 223: 958–967.CrossRefGoogle ScholarPubMed
15.Woods, RP, Jacoboni, M., Mazziota, JC. Bilateral spreading cerebral hypoperfusion during spontaneous migraine headache. N Engl J Med 1994; 331: 1689–1692.CrossRefGoogle ScholarPubMed
16.Burnstock, G. Pathophysiology of migraine: a new hypothesis. Lancet 1981; 1: 1397.CrossRefGoogle Scholar
17.Sicuteri, F, Testi, H, Anselmi, B. Biochemical investigation in headache: increase in hydroxyindolacetic acid excretion during migrazine. Int Arch Allerg 1961; 19: 55–58.CrossRefGoogle Scholar
18.Anthony, M. The biochemistry of migraine. In: Vinker, PJ, Bruyn, GW, eds. Elsevier Science Publishers B.V., Amsterdam. Handbook of Clinical Neurology, Vol 4: Headache 1986; 85–105.Google Scholar
19.Olesen, J. Migraine and Other Headaches: the Vascular Mechanisms. New York: Raven Press, 1981.Google Scholar
20.Welch, KMA, Nell, J, Chabi, JE, Mathew, NT, Meyer, JS. Cyclic nucleotides study in migraine. Neurology 1976; 26: 380–381.Google Scholar
21.Anthony, M. Biochemical indices of sympathetic activity in migraine. Cephalalgia 1981; 1: 83–89.CrossRefGoogle ScholarPubMed
22.Burnstock, G. The role of adenosine triphosphate in migraine. Biomed Pharmakother 1989; 43: 727–736.CrossRefGoogle ScholarPubMed
23.Guieu, R, Sampieri, F, Pouget, J, Bechis, G, Rochat, H. Adenosine in painful legs and moving toes syndrome. Clin Neuropharm 1994; 5: 460–469.CrossRefGoogle Scholar
24.Guieu, R, Peragut, JC, Roussel, P, et al. Adenosine and neuropathic pain. Pain 1996; 68: 1–4.CrossRefGoogle ScholarPubMed