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Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss

Published online by Cambridge University Press:  11 March 2016

M E Dinc ,
S Ulusoy ,
A Is ,
N N Ayan ,
M O Avincsal ,
C Bicer  and
O Erel
M E Dinc*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Istanbul Gaziosmanpasa Taksim Research and Training Hospital, Istanbul, Turkey
S Ulusoy
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Istanbul Gaziosmanpasa Taksim Research and Training Hospital, Istanbul, Turkey
A Is
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Erciş State Hospital, Van, Turkey
N N Ayan
Affiliation:
Department of Medical Biochemistry, Istanbul Gaziosmanpasa Taksim Research and Training Hospital, Istanbul, Turkey
M O Avincsal
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Istanbul Gaziosmanpasa Taksim Research and Training Hospital, Istanbul, Turkey
C Bicer
Affiliation:
Department of Medical Biochemistry, Dışkapı Yıldırım Bayezit Training and Research Hospital, Ankara, Turkey
O Erel
Affiliation:
Department of Medical Biochemistry, Dışkapı Yıldırım Bayezit Training and Research Hospital, Ankara, Turkey
*
Address for correspondence: Dr Mehmet Emre Dinc, Department of Otolaryngology, Head and Neck Surgery, Istanbul Gaziosmanpasa Taksim Research and Training Hospital, Istanbul 34255, Turkey E-mail: dremredinc@hotmail.com
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Abstract

Objectives:

To investigate a novel oxidative stress marker, thiol/disulphide literature homeostasis, in patients with idiopathic sudden sensorineural hearing loss, and to compare the results with healthy controls for the first time.

Methods:

Thirty-two patients with idiopathic sudden sensorineural hearing loss and 30 healthy individuals were included in the study. Serum native thiol, total thiol and disulphide levels were measured, and disulphide/native thiol and disulphide/total thiol ratios were determined in all subjects.

Results:

Serum native thiol and total thiol levels were significantly lower in patients with sudden sensorineural hearing loss compared with controls (p < 0.05). Of the 32 patients, 25 had lower native thiol levels than controls (333.2 ± 73.9 vs 381.8 ± 35.6 μmol/l, p = 0.002) and 24 had lower total thiol levels (375.1 ± 74.3 vs 426.1 ± 39.3 μmol/l, p = 0.002).

Conclusion:

The changes in oxidative markers evident in a significant number of patients may be associated with oxidative stress, which may, in turn, have caused sudden sensorineural hearing loss in those patients.

Keywords

ThiolsDisulfidesHearing Loss, SuddenOxidative StressReactive Oxygen Species
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 5 , May 2016 , pp. 447 - 452
Copyright
Copyright © JLO (1984) Limited 2016 

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