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Critical Care
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Open Access 01-12-2025 | Matters Arising

Limitation of life-sustaining treatments in Asian ICUs: theory versus practice

Authors: Lowell Ling, Andrew Li, Jason Phua, the MOSAICS II Study Group, for the Asian Critical Care Clinical Trials Group

Published in: Critical Care | Issue 1/2025

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Excerpt

We thank Wang and Zhong for raising the important considerations on limitation or withdrawal of therapy in the MOSAICS II studies [1]. Although limitation or withdrawal of therapy was not part of the exclusion criteria for MOSACIS II, data on subsequent limitation of therapy or withdrawal of therapy during ICU stay was collected but not previously published [2, 3]. Amongst the 4826 patients included in the MOSACIS II secondary analysis on qSOFA prognostic value, only 5.9% (283/4826) had withdrawal of life-sustaining treatments and 5.9% (287/4826) had withholding of life-sustaining treatments [3]. Even amongst those who died within 28 days, only 11.2% (142/1271) and 10.8% (137/1271) had withdrawal or withholding of life-sustaining treatments prior to death. Overall, low rates of limitation of therapy suggest it may not have significantly biased the conclusions drawn about prognostic value of qSOFA in sepsis. …
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Metadata
Title
Limitation of life-sustaining treatments in Asian ICUs: theory versus practice
Authors
Lowell Ling
Andrew Li
Jason Phua
the MOSAICS II Study Group
for the Asian Critical Care Clinical Trials Group
Publication date
01-12-2025
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2025
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-024-05241-2

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