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03-09-2024 | Levodopa | Letter to the Editor

Jaw-opening dystonia in Parkinson’s disease improved by foslevodopa-foscarbidopa continuous subcutaneous infusion: a case report

Authors: Motohiro Okumura, Yohei Mukai, Jun Tanimura, Yuji Takahashi

Published in: Neurological Sciences | Issue 12/2024

Excerpt

Jaw-opening dystonia (JOD) is an unusual manifestation of Parkinson’s disease (PD). Response to botulinum toxin or deep brain stimulation (DBS) has recently been reported in several cases of severe JOD that appeared in on-periods or off-periods [1, 2]. We report the case of a patient with a 14-year history of PD who presented with refractory JOD that could be considered off-, and on- or biphasic-dystonia, that showed significant improvement following treatment by FOslevodopa-foscarbidopa Continuous Subcutaneous (FOCS) infusion. …

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Agarwal PA (2019) Severe Jaw-opening Dystonia as an unusual manifestation of Levodopa‐related wearing‐off in Parkinson’s Disease, and successful treatment with Botulinum Toxin Injection. Mov Disord Clin Pract 6:500–501. https://doi.org/10.1002/mdc3.12782CrossRefPubMedPubMedCentral

Bove F, Piano C, Romito LM, Contarino MF (2022) Severe jaw-opening off-dystonia in Parkinson’s disease masked by effective deep brain stimulation of the subthalamic nucleus. Neurol Sci 43:1449–1450. https://doi.org/10.1007/s10072-021-05780-4CrossRefPubMed

Shiraishi T, Nishikawa N, Mukai Y, Takahashi Y (2020) High levodopa plasma concentration after oral administration predicts levodopa-induced dyskinesia in Parkinson’s disease. Parkinsonism Relat Disord 75:80–84. https://doi.org/10.1016/j.parkreldis.2020.05.022CrossRefPubMed

Rosebraugh M, Liu W, Neenan M, Facheris MF (2021) Foslevodopa/Foscarbidopa is well tolerated and maintains stable levodopa and carbidopa exposure following subcutaneous infusion. J Parkinsons Dis 11:1695–1702. https://doi.org/10.3233/jpd-212813CrossRefPubMedPubMedCentral

Tee TY, Khoo CS, Norlinah MI (2019) Prominent Oromandibular Dystonia as Levodopa-induced Dyskinesia in Idiopathic Parkinson’s Disease. Mov Disord Clin Pract 6:330–331. https://doi.org/10.1002/mdc3.12759CrossRefPubMedPubMedCentral

Title: Jaw-opening dystonia in Parkinson’s disease improved by foslevodopa-foscarbidopa continuous subcutaneous infusion: a case report
Authors: Motohiro Okumura
Yohei Mukai
Jun Tanimura
Yuji Takahashi
Publication date: 03-09-2024
Publisher: Springer International Publishing
Keywords: Levodopa
Dystonic Disorders
Parkinson Disease
Carbidopa
Deep Brain Stimulation
Neurological Tests
Botulinum Toxin
Benserazide
Published in: Neurological Sciences / Issue 12/2024
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-024-07740-0

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Jaw-opening dystonia in Parkinson’s disease improved by foslevodopa-foscarbidopa continuous subcutaneous infusion: a case report

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