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European Archives of Oto-Rhino-Laryngology

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26-12-2023 | Leukoplakia | Laryngology

I-scan combined with laryngovideostroboscopy for predicting malignancy in vocal fold leukoplakia

Authors: Qi Wang, Yi Ling, Yang-Yi-Yi Huang, Lin-Rong Li, Lei Shen, Jian Zhang, Guo-Kang Fan

Published in: European Archives of Oto-Rhino-Laryngology | Issue 3/2024

Abstract

Objective

This study evaluated vocal fold leukoplakia using i-scan combined with laryngovideostroboscopy for risk assessment prediction.

Methods

A total of 141 patients with 218 lesions were enrolled in this study. Morphological characteristics of leukoplakia, assessment of the vascular pattern using i-scan, and vocal fold vibratory function were analyzed.

Results

The number of patients with no, mild, moderate, severe dysplasia, and invasive carcinoma were 68, 40, 17, 46 and 47, respectively. The sensitivity of morphological characteristic, vascular pattern, vibratory function and predictive model were 77.4%, 72%, 69.9%, and 82.8%, respectively. Receiver operating characteristic curve analysis of morphological characteristic, vascular pattern, vibratory function and predictive model were 0.771, 0.824, 0.769, and 0.923, respectively. The results of logistic regression analysis showed that rough morphological types, perpendicular vascular pattern, severe decrease and absence of mucosal waves increased the risk of malignancy (OR = 5.531, 4.973, and 16.992, respectively; P < 0.001).

Conclusions

I-scan combined with laryngovideostroboscopy can improve the differential diagnosis of low-risk and high-risk vocal fold leukoplakia.

Frangez I, Gale N, Luzar B (1997) The interpretation of leukoplakia in laryngeal pathology. Acta Otolaryngol Suppl 527:142–144. https://doi.org/10.3109/00016489709124058CrossRefPubMed

Peng J, Li H, Chen J, Wu XM, Jiang T, Chen XY (2018) Differences in gene expression profile between vocal cord Leukoplakia and normal larynx mucosa by gene chip. J Otolaryngol Head Neck Surg 47:13. https://doi.org/10.1186/s40463-018-0260-4CrossRefPubMedPubMedCentral

Weller MD, Nankivell PC, McConkey C, Paleri V, Mehanna HM (2010) The risk and interval to malignancy of patients with laryngeal dysplasia; a systematic review of case series and meta-analysis. Clin Otolaryngol 35:364–372. https://doi.org/10.1111/j.1749-4486.2010.02181.xCrossRefPubMed

Garrel R, Uro Coste E, Costes-Martineau V, Woisard V, Atallah I, Remacle M (2020) Vocal-fold leukoplakia and dysplasia. Mini-review by the French Society of Phoniatrics and Laryngology (SFPL). Eur Ann Otorhinolaryngol Head Neck Dis 137:399–404. https://doi.org/10.1016/j.anorl.2020.01.008CrossRefPubMed

Isenberg JS, Crozier DL, Dailey SH (2008) Institutional and comprehensive review of laryngeal leukoplakia. Ann Otol Rhinol Laryngol 117:74–79. https://doi.org/10.1177/000348940811700114CrossRefPubMed

Mau T (2010) Diagnostic evaluation and management of hoarseness. Med Clin North Am 94:945–960. https://doi.org/10.1016/j.mcna.2010.05.010CrossRefPubMed

Kim CM, Chhetri DK (2020) Triological best practice: when is surgical intervention indicated for vocal fold leukoplakia? Laryngoscope 130:1362–1363. https://doi.org/10.1002/lary.28527CrossRefPubMedPubMedCentral

Lu G, Guo W, Zhang Q, Song XC (2021) Endoscopic diagnosis value of narrow band imaging Ni classification in vocal fold leukoplakia and early glottic cancer. Am J Otolaryngol 42:102904. https://doi.org/10.1016/j.amjoto.2021.102904CrossRefPubMed

Sejad A, Kartik V, Niranjan S, Narinder S, Mark S, Isabelle H, Faruque R (2020) Utility of narrowband imaging in the diagnosis of laryngeal leukoplakia: systematic review and meta-analysis. Head Neck 42:3427–3437. https://doi.org/10.1002/hed.26428CrossRef

10.

Chen M, Li C, Yang Y, Cheng L, Wu HT (2019) A morphological classification for vocal fold leukoplakia. Braz J Otorhinolaryngol 85:588–596. https://doi.org/10.1016/j.bjorl.2018.04.014CrossRefPubMed

11.

Arens C, Piazza C, Andrea M, Frederik GD, Robin EATG, Susanne VZ, Giorgio P (2016) Proposal for a descriptive guideline of vascular changes in lesions of the vocal folds by the committee on endoscopic laryngeal imaging of the European Laryngological Society. Eur Arch Otorhinolaryngol 273:1207–1214. https://doi.org/10.1007/s00405-015-3851-yCrossRefPubMed

12.

Barnes L, Eveson JW, Reichart P, Sidransky D (2005) World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Lyon: IARC Press. https://tumourclassification.iarc.who.int/welcome/#. Accessed 1 Oct 2020.

13.

Kizil Y, Aydil U, Yilmaz M (2012) Vocal cord leukoplakia: characteristics and pathological significance. Int J Phonosurg Laryngol 2:9–13CrossRef

14.

Zeitels SM, Casiano RR, Gardner GM, Norman DH, James AK, Clark AR (2002) Management of common voice problems: committee report. Otolaryngol Head Neck Surg 126:333–348. https://doi.org/10.1067/mhn.2002.123546CrossRefPubMed

15.

Lee DH, Yoon TM, Lee JK, Sang CL (2015) Predictive factors of recurrence and malignant transformation in vocal cord leukoplakia. Eur Arch Otorhinol 272:1719–1724. https://doi.org/10.1007/s00405-015-3587-8CrossRef

16.

Cui W, Xu W, Yang Q, Rong H (2017) Clinicopathological parameters associated with histological background and recurrence after surgical intervention of vocal cord leukoplakia. Medicine (Baltimore) 96:e7033. https://doi.org/10.1097/MD.0000000000007033CrossRefPubMed

17.

Young CK, Lin WN, Lee LY, Lee LA, Hsin LJ, Liao CT, Li HY, Chen IH, Fang TJ (2015) Laryngoscopic characteristics in vocal leukoplakia: inter-rater reliability and correlation with histology grading. Laryngoscope 125:E62-66. https://doi.org/10.1002/lary.24884CrossRefPubMed

18.

Fang TJ, Lin WN, Lee LY, Young CK, Lee LA, Chang KP, Liao CT, Li HY, Yen TC (2016) Classification of vocal fold leukoplakia by clinical scoring. Head Neck 38:E1998-2003. https://doi.org/10.1002/hed.24368CrossRefPubMed

19.

Zhang N, Cheng L, Chen M, Chen J, Yang Y, Xie M, Li C, Chen XL, Zhou L, Wu HT (2017) Relationship between laryngoscopic and pathological characteristics of vocal cords leukoplakia. Acta Otolaryngol 137:1199–1203. https://doi.org/10.1080/00016489.2017.1347826CrossRefPubMed

20.

Ni XG, He S, Xu ZG, Gao L, Lu N, Yuan Z, Zhang YM, Yi JL, Wang XL, Zhang L, Li XY, Wang GQ (2011) Endoscopic diagnosis of laryngeal cancer and precancerous lesions by narrow band imaging. J Laryngol Otol 125:288–296. https://doi.org/10.1017/S0022215110002033CrossRefPubMed

21.

Ahmadzada S, Vasan K, Sritharan N, Narinder S, Mark S, Isabelle H, Faruque R (2020) Utility of narrowband imaging in the diagnosis of laryngeal leukoplakia: systematic review and meta-analysis. Head Neck 42:3427–3437. https://doi.org/10.1002/hed.26428CrossRefPubMed

22.

Guo CG, Ji R, Li YQ (2015) Accuracy of i-Scan for optical diagnosis of colonic polyps: a meta-analysis. PLoS ONE 10:e0126237. https://doi.org/10.1002/hed.26428CrossRefPubMedPubMedCentral

23.

Lee YC, Eun YG, Park IS (2018) The diagnostic value of i-scan image-enhanced endoscopy in the diagnosis of oral cavity leukoplakia. Korean J Head Neck Oncol 34:29–34CrossRef

24.

Pietruszewska W, Morawska J, Rosiak O, Agata L, Hanna K, Małgorzata W (2021) Vocal fold leukoplakia: which of the classifications of white light and narrow band imaging most accurately predicts laryngeal cancer transformation? Proposition for a diagnostic algorithm. Cancers (Basel) 30:3273. https://doi.org/10.3390/cancers13133273CrossRef

25.

Anis MM (2019) Correlating laryngoscopic appearance of laryngeal lesions with histopathology. Laryngoscope 129:1308–1312. https://doi.org/10.1002/lary.27585CrossRefPubMed

26.

Rzepakowska A, Sobol M, Sielska-Badurek E, Kazimierz N, Ewa OW (2020) Morphology, vibratory function, and vascular pattern for predicting malignancy in vocal fold leukoplakia. J Voice 34:812.e9-812.e15. https://doi.org/10.1016/j.jvoice.2019.04.001CrossRefPubMed

27.

Li J, Xu W, Cheng LY (2017) Application of stroboscopy and narrow band imaging endoscopy in the diagnosis of vocal cord leukoplakia. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 52:806–811. https://doi.org/10.3760/cma.j.issn.1673-0860.2017.11.002CrossRefPubMed

28.

Peretti G, Piazza C, Berlucchi M, Johnny C, Marco G, Piero N (2003) Pre-and intraoperative assessment of mid-cord erythroleukoplakias: a prospective study on 52 patients. Eur Arch Otorhinolaryngol 260:525–528. https://doi.org/10.1007/s00405-003-0584-0CrossRefPubMed

29.

El-Demerdash A, Fawaz SA, Sabri SM, Ahmed S, Rabie H (2015) Sensitivity and specificity of stroboscopy in preoperative differentiation of dysplasia from early invasive glottic carcinoma. Eur Arch Otorhinolaryngol 272:1189–1193. https://doi.org/10.1007/s00405-015-3530-zCrossRefPubMed

30.

Ni XG, Zhu JQ, Zhang QQ, Zhang BG, Wang GQ (2019) Diagnosis of vocal cord leukoplakia: The role of a novel narrow band imaging endoscopic classification. Laryngoscope 129:429–434. https://doi.org/10.1002/lary.27346CrossRefPubMed

Title: I-scan combined with laryngovideostroboscopy for predicting malignancy in vocal fold leukoplakia
Authors: Qi Wang
Yi Ling
Yang-Yi-Yi Huang
Lin-Rong Li
Lei Shen
Jian Zhang
Guo-Kang Fan
Publication date: 26-12-2023
Publisher: Springer Berlin Heidelberg
Keywords: Leukoplakia
Leukoplakia
Endoscopy
Published in: European Archives of Oto-Rhino-Laryngology / Issue 3/2024
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-023-08390-2

ERS Congress 2024

Springer Medicine

I-scan combined with laryngovideostroboscopy for predicting malignancy in vocal fold leukoplakia

Abstract

Objective

Methods

Results

Conclusions

ERS Congress 2024

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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