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04-05-2024 | Keratoplasty | COHORT PROFILE

The Chinese keratoconus (CKC) cohort study

Authors: Kaili Yang, Xiaotian Liu, Liyan Xu, Yuwei Gu, Qi Fan, Shanshan Yin, Yifan Wang, Yi Yuan, Anqi Chang, Yonghao Zang, Chenchen Yin, Chenjiu Pang, Chongjian Wang, Shengwei Ren

Published in: European Journal of Epidemiology

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Abstract

The Chinese keratoconus (CKC) cohort study is a population-based longitudinal prospective cohort study in the Chinese population involving a clinical database and biobanks. This ongoing study focuses on the prevention of KC progression and is the first to involve the effect of gene‒environment interactions on KC progression. The CKC cohort is hospital-based and dynamic and was established in Zhengzhou, China; KC patients (n = 1114) from a large geographical area were enrolled from January 2019 to June 2023, with a mean age of 22.23 years (6‒57 years). Demographic details, socioeconomic characteristics, lifestyle, disease history, surgical history, family history, and visual and social function data are being collected using questionnaires. General physical examination, eye examination, biological specimen collection, and first-degree relative data were collected and analyzed in the present study. The primary focus of the present study was placed on gene, environment and the effect of gene‒environment interactions on KC progression. The follow-up of the CKC cohort study is expected to include data collection at 3 months, 6 months, and 1 year after the initial examination and then at the annual follow-up examinations. The first follow-up of the CKC cohort study was recorded. A total of 918 patients completed the follow-up by June 1, 2023, with a response rate of 82.40%. Aside from the younger age of patients who were followed up, no significant differences were found between patients who were followed up and patients who were not.
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Metadata
Title
The Chinese keratoconus (CKC) cohort study
Authors
Kaili Yang
Xiaotian Liu
Liyan Xu
Yuwei Gu
Qi Fan
Shanshan Yin
Yifan Wang
Yi Yuan
Anqi Chang
Yonghao Zang
Chenchen Yin
Chenjiu Pang
Chongjian Wang
Shengwei Ren
Publication date
04-05-2024
Publisher
Springer Netherlands
Keyword
Keratoplasty
Published in
European Journal of Epidemiology
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-024-01128-2