Skip to main content
Top

Open Access 17-06-2024 | Keratoconus | Cornea

Biomechanical changes following corneal crosslinking in keratoconus patients

Authors: Emilia Felter, Ramin Khoramnia, Maximilian Friedrich, Hyeck-Soo Son, Gerd U. Auffarth, Victor A. Augustin

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology

Login to get access

Abstract

Purpose

To evaluate the biomechanical and tomographic outcomes of keratoconus patients up to four years after corneal crosslinking (CXL).

Methods

In this longitudinal retrospective-prospective single-center case series, the preoperative tomographic and biomechanical results from 200 keratoconus eyes of 161 patients undergoing CXL were compared to follow-up examinations at three-months, six-months, one-year, two-years, three-years, and four-years after CXL. Primary outcomes included the Corvis Biomechanical Factor (CBiF) and five biomechanical response parameters obtained from the Corvis ST. Tomographically, the Belin-Ambrósio deviation index (BAD-D) and the maximal keratometry (Kmax) measured by the Pentacam were analyzed. Additionally, Corvis E-staging, the thinnest corneal thickness (TCT), and the best-corrected visual acuity (BCVA) were obtained. Primary outcomes were compared using a paired t-test.

Results

The CBiF decreased significantly at the six-month (p < 0.001) and one-year (p < 0.001) follow-ups when compared to preoperative values. E-staging behaved accordingly to the CBiF. Within the two- to four-year follow-ups, the biomechanical outcomes showed no significant differences when compared to preoperative. Tomographically, the BAD-D increased significantly during the first year after CXL with a maximum at six-months (p < 0.001), while Kmax decreased significantly (p < 0.001) and continuously up to four years after CXL. The TCT was lower at all postoperative follow-up visits compared to preoperative, and the BCVA improved.

Conclusion

In the first year after CXL, there was a temporary progression in both the biomechanical CBiF and E-staging, as well as in the tomographic analysis. CXL contributes to the stabilization of both the tomographic and biomechanical properties of the cornea up to four years postoperatively.
Literature
20.
go back to reference Kobashi H, Hieda O, Itoi M, Kamiya K, Kato N, Shimazaki J, Tsubota K, The Keratoconus Study Group Of J (2021) Corneal cross-linking for paediatric Keratoconus: a systematic review and Meta-analysis. J Clin Med 10. https://doi.org/10.3390/jcm10122626 Kobashi H, Hieda O, Itoi M, Kamiya K, Kato N, Shimazaki J, Tsubota K, The Keratoconus Study Group Of J (2021) Corneal cross-linking for paediatric Keratoconus: a systematic review and Meta-analysis. J Clin Med 10. https://​doi.​org/​10.​3390/​jcm10122626
Metadata
Title
Biomechanical changes following corneal crosslinking in keratoconus patients
Authors
Emilia Felter
Ramin Khoramnia
Maximilian Friedrich
Hyeck-Soo Son
Gerd U. Auffarth
Victor A. Augustin
Publication date
17-06-2024
Publisher
Springer Berlin Heidelberg
Keyword
Keratoconus
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-024-06549-z