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Current Nutrition Reports
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28-09-2024 | Ionizing Radiation | REVIEW

Food Polyphenols in Radiation-Related Diseases: The Roles and Possible Mechanisms

Authors: Kaidi Li, Maxin Ji, Xiujuan Sun, Junyan Shan, Guangyue Su

Published in: Current Nutrition Reports | Issue 4/2024

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Abstract

Purpose of Review

As science and technology continue to evolve, the potential harm of radiation to the human body cannot be overlooked. Radiation has the capacity to inflict cellular and body-wide damage. Polyphenols are a group of naturally occurring compounds that are found in an array of plant foods. Scientific studies have demonstrated that these compounds possess noteworthy anti-radiation efficacy. Furthermore, they have been observed to be less toxic at higher doses. In the present review, we discussed the mechanisms of ionizing radiation damage and the progress in the research on the radiation resistance mechanism of polyphenol compounds, to provide guidance for the prevention and treatment of radiation related diseases.

Recent Findings

Food polyphenols can reduce the oxidative damage caused by ionizing radiation, clear free radicals, reduce DNA damage, regulate NF-KB, MAPK, JAK/STAT, Wnt and other signaling pathways, improve immune function, and have significant protective effects on radiation-induced inflammation, fibrosis, cancer and other aspects. In addition, it also has significant dual effects on radiation sensitization and radiation protection.

Summary

Food polyphenols come from a wide range of sources, are abundant in daily food, and have no toxic side effects, demonstrating that food polyphenols have great advantages in preventing and treating radiation-related diseases.
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Metadata
Title
Food Polyphenols in Radiation-Related Diseases: The Roles and Possible Mechanisms
Authors
Kaidi Li
Maxin Ji
Xiujuan Sun
Junyan Shan
Guangyue Su
Publication date
28-09-2024
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 4/2024
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-024-00582-4

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