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International Journal of Clinical Oncology

Issue 10/2025 Including Invited Reviews on Significance of BRCA genetic test for breast cancer

Content (29 Articles)

Carcinogenic form and characteristics of BRCA pathogenic variant breast cancer

Takaaki Fujii

The role of BRCA1/2 genetic testing in perioperative breast cancer management: advancing shared decision-making and personalized care

Sayaka Obayashi, Mayu Aoki, Keiko Tanabe, Yuko Nakazawa, Misato Ogino, Takaaki Fujii, Ken Shirabe

Opioid switching to improve delirium symptoms in patients with cancer: a systematic review

Kousuke Yamanaka, Takaaki Hasegawa, Yoshinobu Matsuda, Shinichiro Inoue, Hitoshi Tanimukai, Saho Wada, Jun Kako, Yoshinobu Matsuda, Shinichiro Inoue, Jun Kako, Hitoshi Tanimukai, Saho Wada, Tetsuro Ishida, Tetsuya Ito, Shuji Inada, Nozomu Oya, Akiharux Okamoto, Yoshiaki Okamoto, Yusuke Kanno, Yuuichi Kitaura, Masamitsu Kobayashi, Yoshinori Saeki, Kaori Shinsato, Koji Sugano, Mari Takeuchi, Kazuyuki Niki, Takaaki Hasegawa, Saki Harashima, Takatoshi Hirayama, Takafumi Miyoshi, Shuntaro Yasuda, Kousuke Yamanaka, Yoshihiro Yamamoto, Masafumi Yoshimura

A systematic review and meta-analysis of x-ray therapy versus proton beam therapy for pediatric central nervous system germ cell tumors: TRP-Germinoma 2025

Sho Hosaka, Masashi Mizumoto, Hiroko Fukushima, Takashi Iizumi, Takashi Saito, Masako Inaba, Ryoko Suzuki, Yinuo Li, Kei Nakai, Shosei Shimizu, Yoshiko Oshiro, Kazushi Maruo, Hidetoshi Takada, Hideyuki Sakurai

Is daikenchuto effective for postoperative intestinal dysfunction after gastroenterological cancer surgery? An updated meta-analysis of randomized controlled trials

  • Review Article

Hideki Kogo, Akihisa Matsuda, Yasuyuki Negishi, Rimpei Morita, Hiroshi Yoshida

Targeting miRNAs in renal cell carcinoma: emerging therapeutic strategies

Rabab S. Hamad, Ghadir A. Sayed, Mai A. Abd-Elmawla, Sherif S. Abdel Mageed, Ahmed I. Abulsoud, Mohamed Bakr Zaki, Osama A. Mohammed, Shereen Saeid Elshaere, Ahmed E. Elesawy, Samy Y. Elkhawaga, Walaa A. El-Dakroury, Mustafa Ahmed Abdel-Reheim, Abdullah Ayed, Ahmed S. Doghish

A cross-sectional study on the first-in-human trials of anticancer drugs in Japan and the United States and the probability of approval

  • Open Access
  • Original Article

Akari Mukaida, Hideki Maeda

Impact of prior COVID-19 infection on perioperative outcomes in non-small cell lung cancer patients: a prospective observational cohort study

Hanbo Pan, Fan Shen, Ningyuan Zou, Yu Tian, Jiaqi Zhang, Yixing Tao, Hongda Zhu, Jia Huang, Qingquan Luo

Real-world treatment outcomes before and after chemoimmunotherapy approval in EGFR-mutant NSCLC after EGFR-TKI failure: a Japanese cohort study

Kenji Morimoto, Tadaaki Yamada, Naoki Furuya, Hisashi Tanaka, Akihiro Yoshimura, Tomohiro Oba, Makoto Hibino, Takahito Fukuda, Yasuhiro Goto, Akira Nakao, Shinsuke Ogusu, Yuta Okazaki, Taishi Harada, Takayo Ota, Ken Masubuchi, Koji Mikami, Tae Hata, Shoki Matsumoto, Ryoichi Honda, Koji Date, Yusuke Chihara, Koichi Takayama

Clinical and biological impact of SNAT7 in lung adenocarcinoma: implications for prognosis and treatment

  • Original Article

Asato Hashinokuchi, Naoki Haratake, Yuya Ono, Takumi Tomonaga, Giacomo Bassi, Kyoto Matsudo, Fumihiko Kinoshita, Taichi Matsubara, Mikihiro Kohno, Tomoyoshi Takenaka, Yoshinao Oda, Tomoharu Yoshizumi

Real-world treatment patterns and clinical outcomes with tucatinib-based therapy in patients with HER2-positive metastatic breast cancer: analyses of two nationwide administrative health claims databases

Carey Anders, Edward Neuberger, Naomi R. M. Schwartz, Karen Bartley, Shu Wang, Yutong Liu, Brian T. Pittner, Peter A. Kaufman, Jane Meisel

Clinical advantages of two vs. three courses of neoadjuvant chemotherapy using docetaxel + cisplatin + 5-fluorouracil to improve preoperative nutritional status and mitigate decreasing skeletal muscle in resectable esophageal cancer

Kazuaki Matsui, Yutaka Miyawaki, Ryota Kobayashi, Masatoshi Yoshizawa, Tetsuro Toriumi, Gen Ebara, Hiroshi Sato, Shinichi Sakuramoto

First-line pembrolizumab plus chemotherapy for participants in Japan with gastric or gastroesophageal junction adenocarcinoma: subgroup analysis of the phase 3 KEYNOTE-859 study

Hisateru Yasui, Masaki Aizawa, Kensei Yamaguchi, Akihito Kawazoe, Hiroki Hara, Masahiro Tsuda, Hirokazu Shoji, Naotoshi Sugimoto, Nobuhiro Shibata, Kenji Amagai, Yasuhiro Choda, Shiro Iwagami, Taito Esaki, Shigenori Kadowaki, Shinichi Shiratori, Shirong Han, Sonal Bordia, Kohei Shitara

Risk factors for second primary cancers in patients with curatively resected gastric cancer

Kiyoshi Wakao, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Junichi Takamizawa, Mayuko Ueda, Norihiro Yuasa

Effect of pretreatment vascular endothelial growth factor inhibitor use on the safety and efficacy of trifluridine/tipiracil plus bevacizumab in patients with metastatic colorectal cancer

Koshiro Fukuda, Hiroki Osumi, Akira Ooki, Daisaku Kamiimabeppu, Shohei Udagawa, Shota Fukuoka, Mariko Ogura, Takeru Wakatsuki, Keisho Chin, Mitsuhiro Fujishiro, Kensei Yamaguchi, Eiji Shinozaki

Predictors of long‑term survival in patients with stage IV colorectal cancer with primary tumor resection: a multi-center retrospective analysis

Kiyoaki Sugiura, Tatsuki Kato, Junya Aoyama, Go Oshima, Hiroto Kikuchi, Koji Okabayashi, Satoshi Aiko, Yuko Kitagawa

Efficacy and safety of fruquintinib in patients with refractory metastatic colorectal cancer: a FRESCO-2 subgroup analysis of patients enrolled in Japan

Daisuke Kotani, Takayuki Yoshino, Toshiki Masuishi, Yu Sunakawa, Atsuo Takashima, Kentaro Yamazaki, Hisato Kawakami, Tomohiro Nishina, Yoshito Komatsu, Taito Esaki, Cathy Eng, Stacey Ukrainskyj, Rajash Pallai, Shivani Nanda, Zhao Yang, William Schelman, Marek Kania, Taroh Satoh

Comparison of clinical features by primary site in patients with biliary tract cancer who received gemcitabine-based chemotherapy: an exploratory analysis of JCOG1113

Yuko Suzuki, Masafumi Ikeda, Junki Mizusawa, Yusuke Sano, Chigusa Morizane, Takuji Okusaka, Satoshi Kobayashi, Hiroshi Imaoka, Takeshi Terashima, Naohiro Okano, Haruo Miwa, Akiko Todaka, Satoshi Shimizu, Nobumasa Mizuno, Sohei Satoi, Keiji Sano, Kazutoshi Tobimatsu, Akio Katanuma, Masato Ozaka, Makoto Ueno

Survival impact and recurrence prediction using oncologic resectability classification in hepatocellular carcinoma following hepatic resection: a Japanese multi-center study

Norifumi Iseda, Shinji Itoh, Mizuki Ninomiya, Hiroto Kayashima, Takashi Motomura, Takuma Izumi, Takeo Toshima, Shohei Yoshiya, Yo-Ichi Yamashita, Kengo Fukuzawa, Toru Utsunomiya, Shoichi Inokuchi, Takashi Maeda, Eiji Tsujita, Kazutoyo Morita, Hidefumi Higashi, Keishi Sugimachi, Takahiro Tomino, Ryosuke Minagawa, Koichi Kimura, Hideaki Uchiyama, Noboru Harada, Tomoharu Yoshizumi

Burden and trajectories of biliary tract malignancies in Taiwan from 1998 to 2022

Chung-Hsin Tsai, I.-Hung Chien, Shih-Ping Cheng

Impact of body mass index on the efficacy of immune combination therapy in metastatic renal cell carcinoma: a multicenter study in Japan

Toshiki Anami, Takanobu Motoshima, Yuto Matsushita, Takahiro Kojima, Shimpei Yamashita, Hisanori Taniguchi, Keisuke Monji, Ryo Ishiyama, Yoshihide Kawasaki, Takuma Kato, Shuichi Tatarano, Kimihiko Masui, Eijiro Nakamura, Tomoyuki Kaneko, Makito Miyake, Hiroshi Kitamura, Hideaki Miyake, Tomomi Kamba

Role of cystatin C-based sarcopenia index in predicting postoperative infectious complications after major urologic cancer surgery

Ryo Andy Ogasawara, Shugo Yajima, Naoki Imasato, Tomonori Kanagawa, Minoru Inoue, Kohei Hirose, Ken Sekiya, Madoka Kataoka, Yasukazu Nakanishi, Hitoshi Masuda

Trends in real-world outcomes of patients with metastatic renal cell cancer in the recent treatment era: a single-institution analysis

Yasutomo Nakai, Shunki Nakagawa, Yutaka Kurahashi, Shu Okamoto, Yuichiro Nakamura, Yujiro Hayashi, Norihiko Kawamura, Akira Nagahara, Kazuo Nishimura, Masashi Nakayama

Efficacy of cisplatin-based neoadjuvant chemotherapy and risk factors for residual extravesical disease in muscle-invasive bladder cancer: insights from a nationwide cohort

Ryoichi Saito, Rikiya Taoka, Jun Miki, Wataru Fukuokaya, Yoshiyuki Matsui, Shingo Hatakeyama, Takashi Kawahara, Ayumu Matsuda, Taketo Kawai, Tomokazu Sazuka, Minoru Kato, Takeshi Sano, Fumihiko Urabe, Soki Kashima, Hirohito Naito, Yoji Murakami, Makito Miyake, Kei Daizumoto, Yuto Matsushita, Takuji Hayashi, Junichi Inokuchi, Yusuke Sugino, Kenichiro Shiga, Noriya Yamaguchi, Shingo Yamamoto, Keiji Yasue, Takashige Abe, Shotaro Nakanishi, Katsuyoshi Hashine, Masato Fujii, Kiyoaki Nishihara, Hiroaki Matsumoto, Shuichi Tatarano, Koichiro Wada, Sho Sekito, Ryo Maruyama, Naotaka Nishiyama, Hiroyuki Nishiyama, Hiroshi Kitamura, Hidefumi Kinoshita

Post-marketing surveillance of radium-223 chloride in Japanese patients with castration-resistant prostate cancer with bone metastasis—final analysis of 3-year extended follow-up focusing on bone fractures

Naoya Masumori, Makoto Hosono, Shunji Takahashi, Yoshiyuki Kakehi, Hirotsugu Uemura, Toshiyuki Sunaya, Kako Shimotsumagari, Yasuhiro Matsuba, Masatoshi Adachi, Haruka Kakiuchi, Seigo Kinuya

Clinical utility and characteristics of comprehensive genomic profiling tests in patients with gynecologic cancer: a multi-institutional survey in Kinki District, Japan

Shinichi Terada, Tomohito Tanaka, Yoji Hisamatsu, Masato Kita, Mana Taki, Koji Yamanoi, Hiroyuki Fujita, Seiko Kato, Hisashi Kataoka, Taisuke Mori, Hidekatsu Nakai, Noriomi Matsumura, Hiroki Nishimura, Tsukuru Amano, Naohisa Masuko, Yoshito Terai, Madoka Suruga, Makoto Murakami, Mariya Kobayashi, Satoshi Nakagawa, Hisanori Matsumoto, Yusuke Fujikami, Michihide Maeda, Shoji Kamiura, Kyohei Nishikawa, Yosuke Fukui, Tomoko Ueda, Hiroshi Tsubamoto, Sayaka Ueno, Takashi Shibutani, Ayame Teramoto, Yasushi Mabuchi, Kazuhiko Ino, Takahito Motoyama, Takuya Aoki, Ryo Nakazawa, Fuminori Ito, Nao Terayama, Masanori Kanemura, Azusa Sakurai, Yumi Takao, Masahide Ohmichi

The value of vaginal cytology for postoperative surveillance of endometrial cancer

Yuko Watanabe, Eiji Kobayashi, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Kosuke Hiramatsu, Tadashi Iwamiya, Shinya Matsuzaki, Eiji Nakatani, Yutaka Ueda

Optimizing radiation therapy for merkel cell carcinoma: evaluating prognostic factors and treatment outcomes

Minori Niwa, Masanari Niwa, Natsuo Tomita, Hiromichi Ishiyama, Ayaka Uchida, Yukihiko Oshima, Hirota Takano, Masayuki Matsuo, Mayu Kuno, Akifumi Miyakawa, Shinya Otsuka, Toru Matsui, Shintaro Yamamoto, Taiki Takaoka, Dai Okazaki, Akira Torii, Nozomi Kita, Seiya Takano, Motoki Nakamura, Hiroshi Kato, Akimichi Morita, Akio Hiwatashi

Comment on: primary tumor location is a risk factor for postoperative development of sarcopenia as a predictive marker for unfavorable outcomes in patients with colorectal cancer

Erkan Topkan, Duriye Ozturk, Ugur Selek

Sep 25
Issue: 9/2025
Including Invited Reviews on Progress in management of bone and soft tissue tumor
Nov 25
Issue: 11/2025

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Case simulations: Biomarker-driven management of NSCLC (Link opens in a new window)

Do you want to assess your biomarker testing skills and management decisions? Use these simulation-based case studies based on realistic NSCLC scenarios to do so in a practical and secure environment.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window
COMMISSIONED

How-to guide for healthcare professionals: understanding genomic reports

This educational activity was initiated, funded and co-developed by Boehringer Ingelheim and is intended for healthcare professionals in the UK and Ireland only. 

Genomic testing helps inform cancer diagnosis, prognosis, and treatment. A genomic report is generated by the laboratory carrying out next-generation sequencing to analyze biopsy samples. Access this educational microsite to learn more about typical genomic report content and how to interpret test results for patients with cancer.

NP-GB-106631 | Jan 2026

Commissioned by:
  • Boehringer Ingelheim
Learn more
Image Credits
Biomarker-driven management of NSCLC logo/© Springer Health+ IME, DNA double helix structure on a purple background/© 2025 Adobe